Also found in: Dictionary, Acronyms, Encyclopedia, Wikipedia.
1. hypertrophy of the horny layer of the skin, or any disease characterized by it.
2. hypertrophy of the cornea. adj., adj hyperkeratot´ic.
epidermolytic hyperkeratosis a hereditary autosomal dominant form of ichthyosis, present at birth. Characteristics include generalized redness of the skin and severe hyperkeratosis with small, hard wartlike scales over the entire body, accentuated in areas that flex or bend and sometimes involving the palms and soles. In infancy and childhood, there are recurrent bullae, most often on the lower limbs.
follicular hyperkeratosis a skin condition characterized by excessive development of keratin in hair follicles, resulting in rough, cone-shaped, elevated papules, the openings of which are often closed with a white plug of encrusted sebum. Deficiencies of vitamins A and E, B complex vitamins, and essential fatty acids have all been implicated in the etiology. Called also phrynoderma.
hyperkeratosis lenticula´ris per´stans an autosomal dominant skin disorder, usually occurring in the third or fourth decade of life, characterized by pink, red, or yellow to brown scaly papules on the lower leg and back of the foot, and sometimes on the trunk, thigh, arm, back and palm of the hand, or sole of the foot.
n. pl. hyperkerato·ses (-sēz)
Hypertrophy of the cornea or the horny layer of the skin.
hy′per·ker′a·tot′ic (-tŏt′ĭk) adj.
hyperkeratosisDermatology An ↑ in superficial keratinized layers of certain epithelia, skin, and uterine cervix; hyperkeratosis usually represents a reaction to irritation, and generally overlies benign epithelium
hyperkeratosisUndue thickening of the outer layer of the skin so that a dense horny layer, such as a corn or callosity, results. This is a normal and essentially protective response to local pressure. Hyperkeratosis may also occur as an inherited disorder of the palms and the soles, or as ICHTHYOSIS.
Thickening of the horny layer of the epidermis or mucous membrane.