Prospective study of colorectal cancer risk and physical activity, diabetes, blood glucose and BMI: exploring the
hyperinsulinaemia hypothesis.
This compensatory
hyperinsulinaemia of insulin resistance contributes to ovarian androgen excess.
Hyperinsulinaemia in non-cirrhotic haemochromatosis: Impaired hepatic insulin degradation?
Mild maternal hyperglycaemia induced by streptozotocin causes foetal hyperglycaemia,
hyperinsulinaemia and macrosomia (Merzouk et al., 2000; Golalipour et al., 2010, 2012).
Hyperglycaemia and
hyperinsulinaemia delay gastric emptying and small intestinal transit in both diabetic and nondiabetic patients [53], whereas postprandial ghrelin levels correlate inversely with glucose and insulin levels.
This should increase knowledge on regulation of brain transporters and increase the understanding of brain and body response to metabolic disturbances, which in this case consists of an induced paradoxical state of opposing metabolic signals of nutrient surplus (
hyperinsulinaemia) and nutrient scarcity (hypoglycaemia), which would not otherwise occur together.
Hyperinsulinaemia and metabolic syndrome are also highly prevalent among the general population of Indigenous Australians in our region [33, 34]; hyperferritinaemia in the absence of acute infection may potentially reflect sustained
hyperinsulinaemia among our patients.
The importance of truncal and abdominal subcutaneous adipose tissue was shown by us again in another study where sum of four skinfolds strongly predicted fasting
hyperinsulinaemia and HOMA-IR values in Asian Indian children, with a consistent increase in fasting insulin as skinfold thickness increased [18].
The majority of patients underwent screening for hypopituitarism with a tetracosactide test as well as 72-hour fast to exclude endogenous
hyperinsulinaemia, as in our index patient.
Apart from a single state of hyperglycemia, type 2 diabetes is usually accompanied by obesity-induced insulin resistance and
hyperinsulinaemia, which could have a nonnegligible effect on insulin signaling and lead to cardiac hypertrophy [28].
Desbois-Mouthon, "
Hyperinsulinaemia and insulin signalling in the pathogenesis and the clinical course of hepatocellular carcinoma," Liver International, vol.
Testosterone suppression in men with prostate cancer leads to an increase in arterial stiffness and
hyperinsulinaemia. Clin Sci (Lond) 2003;104:195-201.
