Prospective study of colorectal cancer risk and physical activity, diabetes, blood glucose and BMI: exploring the hyperinsulinaemia
This compensatory hyperinsulinaemia
of insulin resistance contributes to ovarian androgen excess.
in non-cirrhotic haemochromatosis: Impaired hepatic insulin degradation?
Mild maternal hyperglycaemia induced by streptozotocin causes foetal hyperglycaemia, hyperinsulinaemia
and macrosomia (Merzouk et al., 2000; Golalipour et al., 2010, 2012).
Hyperglycaemia and hyperinsulinaemia
delay gastric emptying and small intestinal transit in both diabetic and nondiabetic patients , whereas postprandial ghrelin levels correlate inversely with glucose and insulin levels.
This should increase knowledge on regulation of brain transporters and increase the understanding of brain and body response to metabolic disturbances, which in this case consists of an induced paradoxical state of opposing metabolic signals of nutrient surplus (hyperinsulinaemia
) and nutrient scarcity (hypoglycaemia), which would not otherwise occur together.
and metabolic syndrome are also highly prevalent among the general population of Indigenous Australians in our region [33, 34]; hyperferritinaemia in the absence of acute infection may potentially reflect sustained hyperinsulinaemia
among our patients.
The importance of truncal and abdominal subcutaneous adipose tissue was shown by us again in another study where sum of four skinfolds strongly predicted fasting hyperinsulinaemia
and HOMA-IR values in Asian Indian children, with a consistent increase in fasting insulin as skinfold thickness increased .
The majority of patients underwent screening for hypopituitarism with a tetracosactide test as well as 72-hour fast to exclude endogenous hyperinsulinaemia
, as in our index patient.
Apart from a single state of hyperglycemia, type 2 diabetes is usually accompanied by obesity-induced insulin resistance and hyperinsulinaemia
, which could have a nonnegligible effect on insulin signaling and lead to cardiac hypertrophy .
and insulin signalling in the pathogenesis and the clinical course of hepatocellular carcinoma," Liver International, vol.
Testosterone suppression in men with prostate cancer leads to an increase in arterial stiffness and hyperinsulinaemia
. Clin Sci (Lond) 2003;104:195-201.