Diseases such as gastrointestinal and other infections, as well as those caused by excessive inflammation, are all legitimate targets of hyperimmune
Key words: Hyperimmune
colostrum, immunoglobulin, vaccination, mortality, lambs, kids.
To this end, two Inhibition ELISA methods (IEM), using the mAbs or hyperimmune
serum, were developed to determine total anti-CHIKV antibodies.
bovine colostrum as a low-cost, large-scale source of antibodies with broad neutralizing activity for HIV-1 envelope with potential use in microbicides.
Fractionation of hyperimmune
plasma is achieved by digestion of plasma proteins with pepsin at acid pH (Pope, 1939) and ammonium sulfate precipitation.
Even results of observational studies  and randomized controlled trial about the use of hyperimmune
globulin  are conflicting.
For vaccines that are contraindicated or not recommended during pregnancy, and for pathogens for which there are no approved vaccines, passive immunization with hyperimmune
antibody preparations can be an alternative during pregnancy as there are no known risks to the fetus from such preparations .
Savanna monitors have been successfully treated for cryptosporidiosis with gastric administration of hyperimmune
bovine colostrum, but this treatment only decreased the parasite load and did not completely clear infection in snakes and leopard geckos [22-24].
It has also been recently discovered that OTf PC2 extracted from hyperimmune
eggs exerts evident immunological properties [22, 23].
The whole hyperimmune
serum was 5,000-fold diluted in PBS (pH 7.2).
serum from a dog naturally infected with L.