Hypertrophic lichen planus also tends to have more hypergranulosis than HLE.
Hypertrophic lichen planus demonstrates wedge-shaped hypergranulosis and shows less basal cell damage than HLE (B) (hematoxylin-eosin, original magnifications X20 [A] and X400 [B]).
No biopsy specimens from unaffected control legs showed hypergranulosis or acanthosis.
Hypergranulosis Basophilic pyknotic nuclei in keratin layer.
Histologically, first-stage sebaceous nevi are characterized by papillomatous epidermal hyperplasia, hypergranulosis
, hyperkeratosis, and increased numbers of prickle cells.
The lining also showed hypergranulosis
with large, coalescing keratohyaline granules, typical of verrucous lesions (Figure 3).
The stratified squamous epithelium in the exophytic portion was hyperplastic with hyperkeratosis, parakeratosis, and focal hypergranulosis