hypergonadotropic hypogonadism

Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia.
Related to hypergonadotropic hypogonadism: hypogonadotropic hypogonadism


decreased functional activity of the gonads, with retardation of growth, sexual development, and secondary sex characters. The American Association of Clinical Endocrinologists has published “Clinical Practice Guidelines for the Evaluation and Treatment of Hypogonadism in Adult Male Patients.” These are available online at their web site: http://www.aace.com.
hypergonadotropic hypogonadism that associated with secretion of high levels of gonadotropins, as in Klinefelter's syndrome. Called also hypergonadotropic eunuchoidism.
hypogonadotropic hypogonadism that due to lack of gonads or of gonadotropin secretion. Called also hypogonadotropic eunuchoidism.

hy·per·go·nad·o·tro·pic hy·po·go·nad·ism

defective gonadal development or function of the gonads, resulting in elevated levels of gonadotropins.


A gene on chromosome 2p21 that encodes a cell surface receptor for both luteinising hormone and choriogonadotropin, which belongs to the G-protein-coupled receptor 1 family. LHCGR’s activity is mediated by adenylate cyclase-activating G proteins.

Molecular pathology
LHCGR mutations cause a range of disorders affecting male secondary sexual development, such as familial male precocious puberty (testotoxicosis), hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty and male pseudohermaphtoditism with Leydig cell hypoplasia.

hypergonadotropic hypogonadism

Primary hypogonadism A condition due to a lack of target organ response to pituitary hormones–eg, FSH and/or LH. See Hypogonadism.