Achlorhydria is an important cause of hypergastrinemia
, which can subsequently lead to the development of GI carcinoid tumors.
Other potential adverse effects may be associated with long-term PPI use, including atrophic gastritis, possibly progressing to metaplasia and adenocarcinoma (8); hypergastrinemia
(an increase in circulating gastrin hormone that has been associated with the development of carcinoid tumors of the gastric mucosa in rats (9)); and other problems.
This situation is curiously reminiscent of gastric carcinoids arising in a background of NE cell hyperplasia in a setting of hypergastrinemia
Second," he wrote, "acid inhibition may induce hyperparathyroidism, which directly decreases bone mineral density, through hypergastrinemia
, although this is controversial.
Cure of Helicobacter pylori infection in atrophic body gastritis patients does not improve mucosal atrophy but reduces hypergastrinemia
and its related effects on body ECL-cell hyperplasia.
Furthermore, for patients also treated with the proton-pump inhibitor (PPI) drug omeprazole, Aphton showed the reduction of the many-fold increase in gastrin levels induced by omeprazole, a condition known as hypergastrinemia
, to pre-meal levels of gastrin.
increases the risk of gastric polyps and may be implicated in gastric and colon cancer.
3) Type 1 tumors arising in the setting of atrophic gastritis with associated hypergastrinemia
are the most common.
A case of multicentric gastric carcinoids without hypergastrinemia
Serum chemistry tests showed mild hypergastrinemia
(106 pg/ml), but the glucagon level was normal (25 pg/ml), as were the levels of pro-insulin, somatostatin, and pancreatic polypeptide.
On the basis of our results, future experimental approaches should include the use of more potent inhibitors of the proton pump and other drugs able to induce a severe hypergastrinemia
in a short time.
Examples include the need to determine the status of acid secretion in patients who have hypergastrinemia
or who are being treated for a gastrinoma.