hypergastrinemia

hypergastrinemia

 [hi″per-gas″trin-e´me-ah]
an excess of gastrin in the blood.

hypergastrinemia

an excess of gastrin in the blood. See also zollinger-ellison syndrome.
References in periodicals archive ?
Achlorhydria is an important cause of hypergastrinemia, which can subsequently lead to the development of GI carcinoid tumors.
Other potential adverse effects may be associated with long-term PPI use, including atrophic gastritis, possibly progressing to metaplasia and adenocarcinoma (8); hypergastrinemia (an increase in circulating gastrin hormone that has been associated with the development of carcinoid tumors of the gastric mucosa in rats (9)); and other problems.
This situation is curiously reminiscent of gastric carcinoids arising in a background of NE cell hyperplasia in a setting of hypergastrinemia.
Second," he wrote, "acid inhibition may induce hyperparathyroidism, which directly decreases bone mineral density, through hypergastrinemia, although this is controversial.
Cure of Helicobacter pylori infection in atrophic body gastritis patients does not improve mucosal atrophy but reduces hypergastrinemia and its related effects on body ECL-cell hyperplasia.
Furthermore, for patients also treated with the proton-pump inhibitor (PPI) drug omeprazole, Aphton showed the reduction of the many-fold increase in gastrin levels induced by omeprazole, a condition known as hypergastrinemia, to pre-meal levels of gastrin.
Hypergastrinemia increases the risk of gastric polyps and may be implicated in gastric and colon cancer.
3) Type 1 tumors arising in the setting of atrophic gastritis with associated hypergastrinemia are the most common.
A case of multicentric gastric carcinoids without hypergastrinemia.
Serum chemistry tests showed mild hypergastrinemia (106 pg/ml), but the glucagon level was normal (25 pg/ml), as were the levels of pro-insulin, somatostatin, and pancreatic polypeptide.
On the basis of our results, future experimental approaches should include the use of more potent inhibitors of the proton pump and other drugs able to induce a severe hypergastrinemia in a short time.
Examples include the need to determine the status of acid secretion in patients who have hypergastrinemia or who are being treated for a gastrinoma.