At 7 months, most showed only a mild hypergastrinemia
Based on previous research that showed an association between hypergastrinemia
(the presence of excess gastrin in the blood) and CKD, the researchers believed cats with CKD would have decreased gastric pH, compared to healthy cats.
Non-judicious PPIs use is a matter of great concern especially in elderly age group13, who often have multiple co-morbidities, are taking multiple medications, and hence are at an increased risk of long-term PPI-related adverse outcomes, some investigators co-relate inappropriate and long term use of PPIs with pneumonia, Clostridium difficile infection, iron deficiency anemia, bloating, headache, hypergastrinemia
and gastric polyps14-19.
, Type 1 Gastric Carcinoid Tumors; Diagnosis and Management, J Clin Oncol.
Alzheimer's disease CCKBR Withdrawal syndrome, hypergastrinemia
, Huntington's disease, major depression, hyperphagia CHRNA1 Depressive disorder, seizures, psychomotor agitation, schizophrenia, stroke, coronary disease, etc.
and antral G-cell hyperplasia are commonly observed.
Zavros Y, Rieder G, Ferguson A, Merchant JL, Gastritis and hypergastrinemia
due to Acinetobacter lwoffii in mice.
As evidence of the protective role of Hp in GERD, the following arguments are described: the development of Hp-associated gastritis in the fundus is accompanied by a decrease in the hydrochloric acid secretion (by inhibiting the production of histamine along with increased synthesis of interleukin (IL)-1[beta] and tumor necrotizing factor (TNF-a)); proximal gastritis improves the gastroesophageal junction barrier function; hypergastrinemia
associated with Hp infection leads to increased pressure of the lower esophageal sphincter (LES), high urease activity of Hp partially neutralizes the aggressive action of hydrochloric acid; Hp can increase antisecretory effect of main antisecretory drugs--proton pump inhibitors [14, 15, 18].
Achlorhydria is an important cause of hypergastrinemia
, which can subsequently lead to the development of GI carcinoid tumors.
Helicobacter pylori and hypergastrinemia
in children with recurrent abdominal pain.
Other potential adverse effects may be associated with long-term PPI use, including atrophic gastritis, possibly progressing to metaplasia and adenocarcinoma (8); hypergastrinemia
(an increase in circulating gastrin hormone that has been associated with the development of carcinoid tumors of the gastric mucosa in rats (9)); and other problems.
Second," he wrote, "acid inhibition may induce hyperparathyroidism, which directly decreases bone mineral density, through hypergastrinemia
, although this is controversial.