Myenteric ganglia were not affected, and, surprisingly, hyperganglionosis was not present in the ganglionic bowel of si/si animals.
Intestinal neuronal density in childhood: a baseline for the objective assessment of hypo- and hyperganglionosis. Pediatr Pathol.
There was no problem/ controversy regarding diagnosis of aganglionosis but when we talk of ganglionic segments actually it may include the normal number of ganglion cells and allied HDs, which are hypoganglionosis, hyperganglionosis
and immature ganglion cells.
Histologically, most MMIHS patients have normal ganglion cells in the myenteric and submucosal plexuses; however, there have been case reports of decreased ganglia in some patients and hyperganglionosis
and giant ganglia in others .
Key words: Hirschsprung's disease (HD), hypoganglionosis, hyperganglionosis
(IND type B) and immaturity of ganglion cells (IGC).