hyperfiltration theory

hyperfiltration theory

increased glomerular capillary pressure and glomerular hypertrophy as adaptive mechanisms in response to increased dietary protein; suggested as a causative factor in progressive chronic renal failure.
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One explanation brought forward for these observations comes in part from the hyperfiltration theory, described as a paradoxical increase in GFR linked to altered glomerular hemodynamics (Weaver et al.
The hyperfiltration theory, involving a paradoxical initial increase in GFR associated with glomerular hypertension and ultimately ending in glomerulosclerosis and renal failure, is one mechanistic explanation for this pattern (Brenner et al.
The hyperfiltration theory generally refers to clinical renal function.