bronchial hyperresponsiveness

A term referring to exaggerated bronchial constriction of unknown pathogenesis, which most commonly occurs in asthmatics in response to nonspecific provocation (inhalation of various bronchoconstrictors), but also to physical challenges—e.g., exercise, dry or cold air, hypertonic or hypotonic aerosols.
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"The ketogenic diet helps control seizures by reducing fluctuations of blood sugar, which reduces hyperexcitability in the brain," explained Millichap.
In addition to developing oral dexpramipexole for eosinophil associated diseases, Knopp's preclinical Kv7 platform is directed to small molecule treatments for KCNQ2 epileptic encephalopathy and other CNS hyperexcitability disorders.
Isaacs' syndrome is a rare neuromuscular disorder, characterized by hyperexcitability of the peripheral nerves and continuous activation of muscle fibers, due to auto-antibodies directed against the voltage-gated potassium channels (1).
Morvan's syndrome is an autoimmune process which manifests as a triad of peripheral nerve hyperexcitability, autonomic system features (sweating, lacrimation, constipation) and central nervous system features (insomnia, disorientation).
Interruption, disconnection, and hyperexcitability of the neuronal pathways from the diencephalon have all been proposed as mechanisms (Choi et al., 2013; Farias-Moeller et al., 2015).
Epilepsy a disorder with an overall population prevalence of 1%, is characterized by recurrent seizures resulting from the hyperexcitability of neurons throughout the cortex or in localized brain regions [1].
However, the question is why neurostimulation treatment is aimed at increasing cortical excitability (high-frequency rTMS and anodal tDCS) in AD patients who show cortex hyperexcitability. It is hypothesized that hyperexcitability may result from other pathophysiological mechanisms, such as reduced synaptic efficiency or hypoplasticity.[29] Additionally, the overall effect of neuromodulation depends on the state of the brain; therefore, the exact effect of high-frequency rTMS and anodal tDCS in AD patients remains debatable.
Similarly, in our study, there were also indications of increased R2 excitability among patients with akathisia, suggesting the presence of a hyperexcitability state in the brainstem among patients with akathisia, similar to RLS.
7, 2018 (HealthDay News) -- For patients with restless leg syndrome (RLS), the primary motor cortex (M1) exhibits hyperexcitability, which is associated with disease severity, according to a study published recently in Sleep Medicine.
It is thought to develop due to the hyperexcitability of the central nervous system, and the interaction of genetic and environmental factors have a role in the pathophysiology.