Normal diploidy was revealed in 21 cases, whereas a hyperdiploid
karyotype, showing both numerical and structural changes, was revealed in 5 patients (cases 5, 8, 11, 15, and 21).
Evidence for a single-step mechanism in the origin of hyperdiploid
childhood acute lymphoblastic leukemia.
karyotype was seen with chromosome 13 aberrations in 10 patients, with both chromosome 13 aberrations and P53 deletion in 2 patients and with P53 deletion in 1 patient.
Number of diploid chromosomes : As the chromosomes were small and difficult to differentiate, we sampled 50 cells and only calculated the numbers of hypodiploid, diploid and hyperdiploid
Two studies found that aneuploidy increased in normal human lung fibroblasts after a 30 h exposure to soluble chromate with a specific increase in hypodiploid cells but no increase in hyperdiploid
In contrast, hyperdiploid
cells in ALL have a better prognosis (11,13).
The percentage of hyperdiploid
cells increased from second passage onward in calli grown on 2,4 D/Kinetin, as evidenced by chromosome number and in situ nuclear DNA content (Table II).
They base this determination on the technology's ability to uncover any exfoliated epithelial cells with true aneuploidy or abnormal hyperdiploid
(S + G2M) DNA values > 15 per cent).
Recent studies have shown that patients with hyperdiploid
ALL (> 50 chromosomes per leukemia cell) have a generally favorable prognosis, particularly those with extra copies of chromosomes 4, 10 and 17.
Hypodiploid and hyperdiploid
karyotypes were defined as having <45 and >46 chromosomes, respectively.
Gains of chromosome 22 by fluorescence in situ hybridization in the context of an hyperdiploid
karyotype are associated with aggressive clinical features in meningioma patients.
Dysplastic changes in idiopathic thrombocytopenic purpura and the effect of corticosteroids to increase dysplasia and cause hyperdiploid