hypercortisolism


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hypercortisolism

(hī″pĕr-kort″ĭ-sol″izm) [ hyper- + cortisol + -ism]
Excess levels of cortisol in the blood, caused by administered corticosteroid drugs, an adrenocorticotropic hormone–secreting tumor, or adrenal overproduction of cortisol.

hypercortisolism (Cushing syndrome),

n a genetic or acquired condition resulting in elevated levels of glucocorticoids, often as a result of tumors in adrenal or pituitary glands. Leads to significant weight gain, particularly on the back (causing a “buffalo hump”) and face. More commonly caused by steroid use/abuse, in which case it is called Cushing syndrome medicamentosus.

hypercortisolism

a state of excess production of cortisol; cushing's syndrome.
References in periodicals archive ?
Cushing's syndrome should be considered in hypertensive pregnant patients with remarkable signs of hypercortisolism.
Biochemical and clinical benefits of unilateral adrenalectomy in patients with subclinical hypercortisolism and bilateral adrenal incidentalomas.
Regardless of signs or symptoms, perform screening laboratory tests for 3 types of adrenal hyperfunction: hypercortisolism, hyperaldosteronism, and hypersecretion of catecholamines (pheochromocytoma).
2010) Use of hair cortisol analysis to detect hypercortisolism during active drinking phases in alcoholdependent individuals.
Other endocrine disorders that can contribute to hypertriglyceridemia include acromegaly, hypothyroidism, and hypercortisolism.
For example, the Doberman Pinscher and Shetland Sheepdog are prone to develop hypothyroidism, while the Boston Terrier is prone to hypercortisolism [also known as Cushing's disease].
Patients 7 and 8 had appropriately increased salivary cortisone concentrations and cortisol-to-cortisone ratios within the reference interval, suggesting endogenous hypercortisolism in these 2 patients.
Patients with history of menopause earlier than 40, surgical menopause, secondary amenorrhea longer than 6 months, consuming alcohol and smoking, severe systemic diseases, experienced fractures, and conditions affecting bone density at present or in the past like hypercortisolism, thyrotoxicosis, DM, malabsorption, celiac disease, anorexia nervosa, hyperparathyroidism and rheumatologic disease, on hormone replacement therapy (HRT), taking drugs affecting bone metabolism including calcium and vitamin D, other drugs causing osteoporosis (antiepileptics, streoids, thyroid hormone therapy), receiving thiazide group of diuretics, exercising regularly and diagnosed with any vertebral fracture in T4-L5 interspaces, constituted the exclusion criteria of the study.
The company said that it will be the sole marketer of Korlym and will be marketed as a once-daily oral medicine to control hyperglycemia secondary to hypercortisolism in adult patients with endogenous Cushing's syndrome who have diabetes mellitus type 2 or glucose intolerance and have failed surgery or are not candidates for surgery.
Circadian relationships between interleukin (IL)-6 and hypothalamic-pituitary-adrenal axis hormones: failure of IL-6 to cause sustained hypercortisolism in patients with early untreated rheumatoid arthritis.
Dysregulation of the HPA axis is associated with both hypercortisolism and hypocortisolism, an increased cortisol awakening response (CAR), increased cortisol reactivity to an acute stressor, and a variety of other related syndromes and illnesses (Dickerson & Kemeny, 2004; Nicolson, 2008; Pollard & Ice, 2007).