hypercoagulable state


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Related to hypercoagulable state: Antiphospholipid syndrome

hypercoagulable state

Hypercoagulability, thrombophilia Hematology A condition in which there is an abnormal ↑ in clotting Workup PT, PTT, fibrinogen, anticardiolipin antibodies, APC resistance, factor V Leiden, prothrombin G20210A polymorphism, defects in homocysteine metabolism, protein C, protein S, AT III. See Coagulation, Hereditary thrombophilia, Hypercoagulable state profile.
References in periodicals archive ?
The hypercoagulable state revealed by TEG facilitated the decision of removal and helped in deviation from the available guidelines.
Acute-phase response and the hypercoagulable state in pulmonary tuberculosis.
and Lohrmann and Peters investigated the causes of aortic atheromas, and their studies found that the cause may be a hypercoagulable state, deficiency in one or more components of coagulation-anticoagulation system, secondary to underlying lupus, estrogen therapy, heparin immune reaction, or underlying aortic disease [11].
Endomyocardial and endothelial damage secondary to amyloid deposition [7, 8] and a hypercoagulable state [9] are also thought to be involved.
She took warfarin "for lupus," and it is unclear whether this was due to an associated hypercoagulable state such as antiphospholipid antibody syndrome.
Moreover, patients with diabetes could show hypercoagulability and high levels of coagulation factors [12], and diabetes mellitus, including type 1 and type 2, is associated with the hypercoagulable state through increased thrombotic tendencies [13], even exhibiting prothrombotic milieu which is due to upregulation of coagulation factors and prolongation of clot lysis [14].
Inflammatory bowel disease has been shown to be associated with abnormalities in coagulation and a hypercoagulable state [1-3].
Several idiopathic cases of PVT have also been described where the underlying mechanism is more difficult to understand and could involve a systemic or local hypercoagulable state [1, 8,15-17].
Pathophysiologic mechanisms which contribute to thrombus formation include turbulent blood flow, transient hypercoagulable state, and atherosclerotic process [12].
It may occur accidentally during ligation of the hepatic artery during surgery, after hepatic artery chemoembolization, or in a hypercoagulable state, with related thrombosis formation [5].
Extracellular hemoglobin released by hemolysis also causes increased consumption of nitric oxide and stimulates circulating neutrophils to release uncondensed chromatin and enzymes, which further exacerbates the hypercoagulable state [13,14].
Aortic, celiac axis, and superior mesenteric artery thrombosis associated with sigmoid colon adenocarcinoma and hypercoagulable state. Vasc Endovasc Surg 2009; 43: 284-5.