It is believed that this hypercoagulable
or prothrombotic state of malignancy occurs due to the ability of tumor cells to activate the coagulation system .
The associations between inflammation, hypercoagulable
state, and hemostatic changes are established [4, 5].
Activated protein C resistance (FVL) and thrombosis: factor V mutations causing hypercoagulable
5] Shortened clotting times could, therefore, be the expression of a hypercoagulable
Moreover, in his hypercoagulable
phase, as evidenced by the kaolin cephalin clotting time (P<0.
The resultant hypercoagulable
state of FMF would increase exponentially.
These may be secondary to a variety of factors, such as venous endothelial cell damage, a potential hypercoagulable
state, and the impedance of blood flow or venous stasis (Virchow's triad).
Decreased clotting and clot formation time as well as increased fibrinolysis also have a unique TEG tracing, which correlates with the specific hypocoagulable or hypercoagulable
Manifestations Early-onset Late-onset encephalitis; encephalitis; early-onset late-onset myelitis; myelitis; aseptic cerebellar meningitis dysfunction; Guillain-Barre' syndrome; cranial and peripheral neuropathies Vascular Unclassifiable Occlusion Definition Vasculitic or -thrombotic vascular occlusion* Manifestations Striatal Acute necrosis; disseminated stroke; encephalopsychologic myelitis disorders * Either vasculitic and thrombotic, or both; with or without systemic hypercoagulable
They include individuals with a hypercoagulable
state, endocarditis, a crescendo event, known ipsilateral large-vessel stenosis or occlusion, or CT or MRI evidence of recent infarction.
One of them presented with splenic infarction, which is a rare manifestation of this hypercoagulable
state: only one case, has so far been reported in the medical literature.
workup (protein C, protein S, factor II mutation, antithrombin III level, lupus anticoagulant, MTHFR mutation, cryoglobulin, homocystine, cardiolipin antibody, lipoprotein (a), beta-2 glycoprotein) showed abnormality of Factor V Leiden with heterozygousity for R506Q polymorphism.