Basal cell adenocarcinoma may be more difficult to differentiate with solid ACC; however, lack of clear cytoplasm and hyperchromatic
, angulated nuclei with the presence of peripheral palisaded nuclei in the former may aid in diagnosis.
The tumour cells contained small mildly hyperchromatic
angulated nuclei together with a small amount of eosinophilic to clear cytoplasm (Figure 2B).
These cells have limited cytoplasm and larger hyperchromatic
1c), with scant, eosinophilic cytoplasm and hyperchromatic
and pyknotic nuclei present in a loose fibrous stroma, at places firmly attached to fibrous strands.
Using modified May Grunwald Giemsa (MGG) stain the imprint smears obtained were found to be cellular mainly consisting of irregular, anisocytotic spindle-shaped atypical cells with oval hyperchromatic
Histopathological examination of the specimen obtained from the lesion showed a neoplastic infiltration consisting small, atypic cells with big, round, hyperchromatic
nucleus, narrow cytoplasms, and prominent nucleoulus in some areas, showing high mitotic activity.
The pleomorphic nuclei were apparently variable in shape, from small round hyperchromatic
to very large vesicular forms.
Cases of disseminated neoplasia in bivalve mollusc species are characterized by the presence of large (2-4 times the diameter of normal hemocytes), neoplastic circulating cells that have a hyperchromatic
and often pleomorphic nucleus containing 1 or more prominent nucleoli (Barber 2004), and a high nuclear-tocytoplasmic volume ratio in neoplastic cells (Mix 1975).
Computer-assisted automated imaging screens for dark, hyperchromatic
cells which are reviewed by CTs ensure the worrisome areas on each slide are examined so further diagnostic information can be provided.
One part of the tumor consisted of pleomorphic epithelial cells with hyperchromatic
nuclei and scant cytoplasm, which is typical of HGUC (Fig.
The team found that deletion of the Sirt1 gene in mice resulted in PIN formation; features included cellular hyperplasia, increased Ki67 staining, hyperchromatic
nuclei and prominent nucleoli, as well as a reduced size in prostate.
The tumor cells were small with ill defined cell borders and irregular shaped hyperchromatic
nuclei with inconspicuous nucleoli.