2 (A) Microscopic examination of the cystoprostatectomy specimen demonstrates an extensively invasive, high-grade neoplasm in the urinary bladder (4X); (B) Several areas show a poorly differentiated epithelioid malignancy resembling a poorly differentiated carcinoma (10X); (C) Tumour with more pronounced vascular differentiation, with anastomosing, angular, blood-filled spaces lined by elongated hyperchromatic
atypical cells (10X); (D) Immunohistochemical stains show strong and diffuse cytoplasmic expression of CD31 in the tumour cells (10X); (E) Immunohistochemical stains show strong nuclear expression of ERG in the tumour cells (10X).
In histopathological assessment results it is clear that the control group neurons had normal morphology, round nuclei, prominent nucleolus, and clear cytoplasm, while the ischemia group had many pyramidal cells with pyknotic nuclei, lack of nucleolus, and hyperchromatic
The spindle cells are relatively large, with long, hyperchromatic
, wavy, or "serpentine" nuclei [1, 8].
The aspirate consists of cohesive, streaming clusters of epithelial cells with hyperchromatic
The basal layer is focally palisaded, with hyperchromatic
Histopathology of the resected specimen showed a neoplasm composed of round to polygonal cells which were hyperchromatic
and arranged in nests and clus- ters.
Cytologic criteria were Nuclear morphology (Large nuclei, Anisonucleosis, Hyperchromatic
nuclei, Vesicular nuclei, Chromatin clumping, Prominent nucleoli, Multiple nucleoli), and Cellular morphology (Comet cells, Signet ring cells, Vacuolar cytoplasm, Granular cytoplasm, Apocrine cells, Ractive ductal cells, Squamous cells).
Cells treated with low doses of EGCG appeared medium and round with a hyperchromatic
nucleus after 24 hours of incubation.
Histopathologic examination of the specimen revealed proliferation of plasmacytoid cells with abundant eosinophilic cytoplasm, hyperchromatic
nuclei, cellular pleomorphism with mitotic figures (Fig.
Nuclei of neoplastic melanoblasts are hyperchromatic
, large, with lumpy chromatin and one or more prominent nucleoli.
Microscopically, the mass revealed neoplastic mesenchymal cells having markedly pleomorphic and hyperchromatic
spindle nuclei and moderate to abundant amount of cytoplasm.
Breast incisional biopsy showed monomorphic population large cell with multiple hyperchromatic
nucleoli along with breast tissue (Figure 2).