The nuclei show stratification, hyperchromasia
, and coarse chromatin, but they lack significant variation in sizes and shapes and nuclear atypia.
Occasionally, some binucleated chondrocytes and a slight nuclear hyperchromasia
can be present and may mimic malignancy.
A biopsy revealed few glomeruli with mesangial expansion, diffuse tubular atrophy with hyperchromasia
and enlargement The other patient was a 21-year-old woman who presented with short-term memory dysfunction, numbness in her upper extremities, tingling, irritability, and depression 4 years post transplant.
7) The nuclei are vertically oriented, and there is an increased nuclear-to-cytoplasmic ratio, increased nuclear hyperchromasia
, and a variable degree of pleomorphism and mitotic activity.
Pancreatic intraepithelial neoplasia 2 has nuclear atypia including loss of polarity, nuclear crowding, and some hyperchromasia
with either a flat or papillary architecture (Figure 4, c), whereas PanIN-3 is almost always papillary or micropapillary, may have cribriforming, and has marked nuclear atypia that exceeds that seen in PanIN-2, and may also include macronucleoli and abnormal mitotic figures (Figure 4, d).
It showed bony trabeculae entrapped by lobules of chondrocytes with chondroid matrix exhibiting pleomorphism, hyperchromasia
, mitosis, area of myxoid change and necrosis consistent with well-differentiated chondrosarcoma.
The papillary pattern of ductal tumors consist of a true papillary fronds lined by columnar cells exhibiting a variable degree of nuclear pleomorphism and hyperchromasia
Histopathological examination revealed a polypoid neoplastic growth with focal glandular, tubulocystic and pseudopapillary patterns (figures 2 C, D case 2) composed of large clear cells that had high nuclear-to-cytoplasmic ratio, hyperchromasia
, irregular nuclear membranes and frequent mitoses (figures 2A, B case 2).
Histopathology identified polyhedral epithelial cells arranged in sheets and strands that exhibited nuclear pleomorphism and variable hyperchromasia
The final histological diagnosis of the adipose tissue was that of a benign thoracic lipoma without any evidence of thymic tissue or malignancy, including the absence of any hyperchromasia
, stromal atypia, or lipoblasts.
There was loss of cellular architecture, nuclear duplication and increased infiltration of leucocytes with prominent hyperchromasia
in animals subjected to high fructose fluid intake as well as isoproterenol (Fig.
Injury to the respiratory cells resulted in distortion of the alveolar architecture such as morphologic changes characterized by cell flattening/stretching, hyperchromasia
, and cellular death.