Gilbert syndrome

(redirected from hyperbilirubinaemia I)

fa·mil·i·al non·he·mo·lyt·ic jaun·dice

[MIM*143500]
mild jaundice due to increased amounts of unconjugated bilirubin in the plasma without evidence of liver damage, biliary obstruction, or hemolysis; thought to be due to an inborn error of metabolism in which the excretion of bilirubin by the liver is defective, ascribed to decreased conjugation of bilirubin as a glucuronide or impaired uptake of hepatic bilirubin; autosomal dominant inheritance.

Gilbert syndrome

A benign hereditary condition (OMIM:143500) in which reduced bilirubin transferase activity results in intermittent hyperbilirubinaemia.

Gilbert syndrome

Constitutional liver dysfunction, low-grade chronic hyperbilirubinemia An inherited defect in bilirubin metabolism Clinical Jaundice, weakness, fatigue, nausea, abdominal pain. Cf Criggler-Najjar disease.

Gilbert,

Nicholas A., French physician, 1858-1927.
Gilbert disease - Synonym(s): familial nonhemolytic jaundice
Gilbert syndrome - Synonym(s): familial nonhemolytic jaundice
References in periodicals archive ?
1 Hyperbilirubinaemia is one of the commonest reasons for morbidity in the neonatal period, occurring in around 60% of term newborn babies by 48-72 hours of age, with 5-10% requiring intervention for pathological jaundice.
5 According to a study done in a neonatal unit in Karachi, hyperbilirubinaemia is the third leading cause requiring admission for neonates.
Hyperbilirubinaemia is a common problem in daily practice for paediatricians and neonatologists.
also concluded that follow-up of infants discharged after termination of phototherapy solely for rebound hyperbilirubinaemia is unnecessary.
Neonatal hyperbilirubinaemia is a cause of concern for the parents as well as for the paediatricians.
Conclusion: The use of Bilisphere 360 in the treatment of indirect pathological hyperbilirubinaemia is as effective as exchange transfusion in lowering Total Serum Bilirubin when its level is within 2-3 mg/dl (34-51umol/l) of the exchange level.
The use of Bilisphere 360 in the treatment of indirect hyperbilirubinaemia is as effective as ECT in lowering TSB.
Hyperbilirubinaemia is the result of imbalance between production and excretion of bilirubin by the liver.
Neonatal Hyperbilirubinaemia is a common finding during the first postnatal week.
Jaundice can be one of the earliest symptoms of urinary tract infection therefore investigating for UTI in the infants with unexplained hyperbilirubinaemia is suggested as part of the workup for jaundice.