There is evidence that obese PCOS women have more severe hyperandrogenism
and a significantly higher incidence of anovulatory cycles, oligomenorrhea and/or hirsutism compared to normal weight ones (12) and weight has an effect on the levels of androgens (13), adiponectin, and visfatin (14).
The molecular-genetic basis of functional hyperandrogenism
and the polycystic ovary syndrome.
3) Cushing's syndrome may prevent conception because the associated hypercortisolism and hyperandrogenism
affect normal follicular and endometrial development.
According to the most widely used diagnostic criteria (Rotterdam Criteria for Diagnosis of PCOS), at least two of the following need to be present to confirm a diagnosis (after excluding other causes): oligoovulation and/or anovulation (associated with irregular (or cessation of) menstruation), hyperandrogenism
(demonstrated clinically by increased body hair, and in more severe cases, hair loss), and polycystic ovaries, with the exclusion of other aetiologies.
60,500 from National Welfare Fund for Sportspersons to former athlete Shanthi Sondarajan, who had won a silver medal in Asian Games 2006 at Doha, which was later withdrawn as she was not found eligible to compete in female category because of female hyperandrogenism
The investigation and management of severe hyperandrogenism
pre- and postmenopause: non-tumor disease is strongly associated with metabolic syndrome and typically responds to insulin-sensitization with metformin.
PCOS is characterized by hyperandrogenism
, menstrual disturbance, anovulation, infertility and obesity and, also associated with increased number of cardiovascular risk factors and early atherosclerosis.
However, with the potential for oligomenorrhea to be associated with hyperandrogenism
[particularly increased levels of testosterone outside (or within the higher range) of the physiological limits for normally menstruating women] many athletic women suffering from oligomenorrhea may not, as expected, present with symptoms of energy deficit.
There also were no differences between preadolescents and adolescents in clinical risk factors such as body mass index, acne, hirsutism, alopecia, or hyperandrogenism
, and no differences in biochemical risk factors such as serum total testosterone and free testosterone levels, insulin resistance, HDL levels, triglyceride levels, or fasting glucose levels.
Detection of functional ovarian hyperandrogenism
in women with androgen excess.
They cover its definition, genetics and pathogenesis, the accuracy of diagnostic investigations, adolescent diagnosis and management, ethnic variations, the clinical care of women, quality of life, insulin resistance and the metabolic syndrome, current therapeutic approaches, lifestyle management, long-term health risks, fertility investigations, management of obesity, hyperandrogenism
, and the roles of insulin-sensitizing drugs and alternative therapies.
Leptin, is a key hormone in energy homeostasis and neuroendocrine function, may involve in pathogenesis of hyperandrogenism
and infertility in women with PCOS (57).