Hyperandrogenism


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Hyperandrogenism

Excessive secretion of androgens (male sex hormones).
References in periodicals archive ?
KEY WORDS: Hyperandrogenism, Insulin resistance, PCOS, PCO morphology, Total cholesterol.
Adolescents were considered to have PCOS when two of the following three criteria were met-(1) chronic anovulation characterized by persistent menstrual irregularity for over six months; (2) clinical and/or laboratory hyperandrogenism; and (3) ultrasonographic appearance of the polycystic ovary.
They postulated that hyperandrogenism was the possible etiological factor.
Conclusion All women with acne should be considered for underlying PCOS and asked about their menstrual patterns and examined for other sign of hyperandrogenism. Those who have menstrual disturbances should have hormonal profile determination as well as pelvic ultrasonography for ovarian visualization.
In this study, significant differences were seen in BMI, waist circumference, waist-hip ratio, parameters indicating hyperandrogenism (Ferriman-Gallwey score, testosterone, and androstenedione levels), parameters indicating insulin resistance (deranged oral glucose tolerance test, fasting insu lin, and HOMA-IR), derangements in lipid profile (LDL, HDL, cholesterol, and triglyceride levels), ovarian reserve parameters (AMH, AFC, and ovarian volume), LH levels, and LH-FSH ratio amongst the clomiphene resistant and sensitive groups.
The National Institute of Health (NIH) criteria require anovulation (no ovulation) or oligoovulation (rare ovulation) plus clinical or biochemical signs of hyperandrogenism. The Rotterdam criteria require any two of the following three conditions for diagnosis: anovulation/oligoovulation, hyperandrogenism, and polycystic ovaries revealed by sonogram.
PCOS is characterized by the presence of polycystic ovaries, menstrual dysfunction, infertility and biochemical (elevated androgens) and clinical (hirsutism and/or acne) hyperandrogenism. PCOS is also associated with an increased incidence of cardiovascular disease, type 2 diabetes, dyslipidemia and impaired glucose tolerance.
Radcliffe said it would be 'naive' to think that countries would not actively start cherry-picking girls with hyperandrogenism and forcing them into sport.
Double Olympic 800m gold medallist Caster Semenya, 27, has hyperandrogenism, which some believe gives her an unfair advantage.
KEYWORDS: Acne vulgaris, Androgens, Hyperandrogenism, Acne Severity.
Indian sprinter Dutee Chand has previously successfully appealed to CAS against her exclusion from the 2014 Commonwealth Games in Glasgow in a similar case, claiming rules on hyperandrogenism introduced by the IAAF in 2011 discriminated unfairly against women who naturally produced high levels of testosterone.