Physical therapists, pain psychologists, anesthesiologists, or gynecologists who are facile with nerve blocks, to help tone down hyperalgesic
tissues, in addition to medical and surgical therapy, have the possibility of really improving the lives of women with endometriosis."
BDME (500 mg/kg) produced significant (p < 0.05) analgesic effect in the Randall-Selitto mechanical hyperalgesic
test on day 15.
The biochemical and neuroendocrine bases of the hyperalgesic
(3,4) Sleep deprivation has a hyperalgesic
effect, which leads to decreased pain tolerance and greater severity and pain-related disability.
The drug may be capable of acutely diminishing the [[alpha].sub.1]-aradrenergic-mediated vasoconstriction that is seen in the later stages of the syndrome and the hyperalgesic
state, both of which are generally attributed to receptor upregulation on the vasculature and afferent sensory fibers, respectively [21, 22].
Similarly, upon subcutaneously administering MWCNT at 0.1 mg/kg and 1 mg/kg showed acute inflammation characterized by vasodilatation, edema formation, neutrophil infiltrate, tissue damage and also elicited hyperalgesic
response (as seen by the increase paw withdrawal of animal) .
Piuvezam, "Warifteine, a bisbenzylisoquinoline alkaloid, decreases immediate allergic and thermal hyperalgesic
reactions in sensitized animals," International Immunopharmacology, vol.
response in the tail-withdrawal test is generally attributed to central mechanisms [26, 27].
Parthasarathy et al., "Sleep deprivation is hyperalgesic
in patients with gastroesophageal reflux disease," Gastroenterology, vol.
(68) This process has been called "hyperalgesic
priming," and it has been described as responsible for the switch from acute to longlasting hypersensitivity to inflammatory cytokines.
(2010) investigated the hyperalgesic
effects in healthy individuals, after 3 sessions of mobilization of the lumbar spine, in 3 distinct days with intervals of 48 hours, and observed an increased pain threshold by pressure.
The application of thermal noxious stimuli forms the basis of some widely used tests to detect either hyperalgesic
or analgesic reactions.