Intrathecal administration of the sFKN (14-17), but not full-length FKN (14) induces thermal hyperalgesia
and mechanical allodynia, which is blocked by pretreatment with neutralizing antibody against CX3CR1 (15,16) or neutralized in CX3CR1 knockout mice (18).
As a result, hypersensitivity manifests as both hyperalgesia
and allodynia occurs, for which standard analgesic treatments are unsuccessful.
All patients presented with a disturbance in pinprick sensation, temperature sensation, and/or allodynia or hyperalgesia
, which was in accordance with the clinical manifestations of SFN.
17] Since TRPA1 and TRPV4 are the two key participants in mechanical hyperalgesia
, together with their high co-expression and synergy effect with TRPV1, it is concluded that TRPA1 and TRPV4 mediated mechanical hyperalgesia
is more critical in KOA pain.
2013) Morphine hyperalgesia
gated through microglia-mediated disruption of neuronal Cl(-) homeostasis.
On physical evaluation, she presented pain provoked by typically nonpainful stimuli (allodynia) and hyperalgesia
in the left thoracic region from the root of the fourth thoracic dermatome to the tenth thoracic dermatome.
The plantar incision produced a marked mechanical hyperalgesia
in the injured paw at all of the time points measured in mice treated with vehicle, when compared with the baseline values (B).
Additionally, the report provides an overview of key players involved in therapeutic development for Hyperalgesia
and features dormant and discontinued projects.
This decrease was accepted as a sign of the development of hyperalgesia
in rats (p<0.
The experimental animals were subjected for various behavioral studies for assessment of hyperalgesia
and allodynia carried out on the different day intervals of 0, 1, 7, 14 and 21 days.
February 18, 2016 -- Cleveland Clinic researchers have found evidence in an animal study that modulating neuro-inflammation with stem cell transplants may prove to be an effective strategy to treat both opioid tolerance (OT) and opioid-induced hyperalgesia
was assessed using von Frey monofilaments (VALADAO et al.