Although it is the most used screening method in patients with suspected primary hyperaldosteronemia
, given the low prevalence of this condition, the screening tests are reserved for those patients with resistant hypertension or hypertension associated with hypokalemia (even when hypokalemia is suspected to be secondary to the use of diuretics) (8).
and associated hyperthyroidism," Ann Endocrinol (Paris), vol.
of NBS may minimize/mask the symptoms and laboratory abnormalities of CAH.
According to clinical presentations, the major symptoms include the following: (1) Hypokalemia (2) hyperkaluria (3) metabolic alkalosis (4) hyperreninemia (5) hyperaldosteronemia
(6) exogenous vasopressin insensitivity (7) juxtaglomerular hyperplasia (8) hypochloremia (9) normal blood pressure, and (10) clear family history.
If no such issues are identified, consider a referral to a specialist for further evaluation and to rule out disorders associated with treatment-resistant hypertension, including CKD, renal artery stenosis, hyperaldosteronemia
, sleep apnea, and coarctation of the aorta.
Therefore, we diagnosed the patient with adrenal myelolipoma associated with hyperaldosteronemia
Favre et al., "Hyperaldosteronemia
and activation of the epithelial sodium channel are not required for sodium retention in puromycin-induced nephrosis," Journal of the American Society of Nephrology, vol.
Further, increased sodium retention may be related to a dysregulation that occurs in a regulatory pathway rather than hyperaldosteronemia
(Doucet et al., 2007).
In another patient, myelolipoma was accompanied by hypokalemia and hyperaldosteronemia
. A third patient in our study had stopped growing and developing at 10 years old possibly due to hyperandrogenism, which resulted in negative feedback and reduced growth hormone secretion.