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Related to hyoscyamine: Hyoscyamine sulfate


an anticholinergic and antimuscarinic alkaloid from plant species of the genus Hyoscyamus and others. It is the levorotatory component of atropine with actions similar to those of atropine but with more potent effects. Used primarily as a gastrointestinal or urinary tract antispasmodic agent.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.



hyoscyamine sulfate

Anaspaz, Hyospaz, Levsin, Levsin/SL, Symax, Symax-SL, Symax-SR

Pharmacologic class: Anticholinergic

Therapeutic class: Antispasmodic

Pregnancy risk category C


Competitively inhibits acetylcholine action at autonomic nerve sites, relaxing smooth muscle and decreasing glandular secretions



Tablets: 0.15 mg

hyoscyamine sulfate

Capsules (timed-release): 0.375 mg

Elixir: 0.125 mg/5 ml

Injection: 0.5 mg/ml

Oral solution: 0.125 mg/ml

Tablets: 0.125 mg

Tablets (extended-release): 0.375 mg

Tablets (orally disintegrating): 0.125 mg

Tablets (sublingual): 0.125 mg

Indications and dosages

Adjunct in GI tract disorders; pain and hypersecretion in pancreatitis; cystitis; renal colic; infant colic; acute rhinitis; rigidity, tremors, and hyperhidrosis in Parkinson's disease; partial heart block due to vagal activity

Adults and children ages 12 and older: 0.125 to 0.25 mg (sulfate) P.O. or S.L. two to four times daily, or 0.375 to 0.75 mg (extended-release sulfate) P.O. q 12 hours, or 0.25 to 0.5 mg (sulfate) subcutaneously, I.M., or I.V. two to four times daily p.r.n.

Children ages 2 to 12: In children weighing approximately 50 kg (110 lb), 0.125 mg (sulfate) P.O. q 4 hours p.r.n.; in children weighing approximately 20 kg (40 lb), 0.0625 mg P.O. (sulfate); in children weighing approximately 10 kg (22 lb), 0.031 to 0.033 mg (sulfate) P.O. Don't exceed 0.75 mg/day.

Children ages 2 and younger: In children weighing approximately 7 kg (15 lb), 0.025 (sulfate) P.O. q 4 hours p.r.n.; in children weighing approximately 5 kg (11 lb), 0.0208 mg (sulfate) P.O. q 4 hours p.r.n.; in children weighing approximately 3.4 kg (7.5 lb), 0.0167 mg (sulfate) P.O. q 4 hours p.r.n.; in children weighing approximately 2.3 kg (5 lb), 0.0125 mg (sulfate) P.O. q 4 hours p.r.n.

Before endoscopy or hypotonic duodenography

Adults: 0.25 to 0.5 mg (sulfate) subcutaneously, I.M., or I.V. 5 to 10 minutes before procedure

Preoperatively to inhibit salivation and excessive respiratory secretions

Adults and children older than age 2: 5 mcg/kg (sulfate) I.M., I.V., or subcutaneously 30 to 60 minutes before anesthesia induction

Muscarinic toxicity

Adults: 1 to 2 mg (sulfate) I.V. Additional 1-mg doses may be given I.M. or I.V. q 3 to 10 minutes until muscarinic signs and symptoms subside; doses may be repeated if needed. Patient may need up to 25 mg during first 24 hours. For maintenance, 0.5 to 1 mg P.O. at intervals of several hours until signs and symptoms disappear.


• Hypersensitivity to anticholinergics, alcohol, sulfites, or tartrazine

• Angle-closure glaucoma, synechia

• GU or GI obstructive disease, severe ulcerative colitis

• Renal or hepatic disease

• Neonates or premature infants


Use cautiously in:

• cardiovascular disease, prostatic hypertrophy, reflux esophagitis, brain damage, autonomic neuropathy, hyperthyroidism, glaucoma, Down syndrome, spastic paralysis

• elderly patients

• pregnant (safety not established) or breastfeeding patients

• infants and small children.


• Administer 30 to 60 minutes before meals and at bedtime.

• Give bedtime dose at least 2 hours after last evening meal or snack.

• Be aware that hyoscyamine is given P.O. only, whereas hyoscyamine sulfate may be given P.O., I.M., I.V., sublingually, or subcutaneously.

• Know that a cholinerase reactivator (pralidoxime) is given concomitantly to treat muscarinic toxicity.

Adverse reactions

CNS: confusion, excitement, nervousness, dizziness, light-headedness, headache, insomnia

CV: palpitations, tachycardia

EENT: blurred vision, cycloplegia, increased intraocular pressure, mydriasis, photophobia

GI: nausea, vomiting, constipation, bloating, dry mouth, paralytic ileus

GU: urinary hesitancy or retention, erectile dysfunction, lactation suppression

Skin: flushing, decreased sweating, urticaria, local irritation (with I.M., I.V., or subcutaneous use)

Other: altered taste, allergic reactions (including fever), heat intolerance, anaphylaxis


Drug-drug. Amantadine, antihistamines, antiparkinsonian drugs, disopyramide, glutethimide, meperidine, procainamide, quinidine, tricyclic antidepressants: increased anticholinergic effects

Antacids: decreased hyoscyamine absorption

Atenolol: increased atenolol effects

Ketoconazole: interference with absorption of both drugs

Methotrimeprazine: increased risk of extrapyramidal effects

Phenothiazines: decreased phenothiazine effects, increased anticholinergic effects

Drug-herbs. Jimsonweed: adverse cardiovascular effects

Patient monitoring

• Watch for adverse reactions.

• Check for mental status changes, such as confusion.

• Evaluate fluid intake and output.

• Assess patient's response to temperature changes (especially hot weather). Drug may cause heat intolerance, predisposing patient to heat stroke.

Patient teaching

• Tell patient to take on empty stomach 30 to 60 minutes before meals and at least 2 hours after last evening meal or snack.

• Instruct patient with urinary hesitancy to empty bladder before taking.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs and herbs mentioned above.


McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved


An alkaloid found in hyoscyamus, belladonna, Duboisia, and stramonium; the levorotatory component of the racemic mixture atropine; used as an antispasmodic, analgesic, and sedative; hyoscyamine hydrobromide is used for the same purposes.
Farlex Partner Medical Dictionary © Farlex 2012


A poisonous white crystalline alkaloid, C17H23NO3, isometric with atropine and having similar uses but more potent effects.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.


An alkaloid found in hyoscyamus, belladonna, Duboisia, and stramonium; used as an antispasmodic, analgesic, and sedative; hyoscyamine hydrobromide is used for the same purposes.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012


An ATROPINE-like drug used to relax smooth muscle spasm, as in colic, and for its sedative effect.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005


Alkaloid; used as an antispasmodic, analgesic, and sedative.
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
Etude de la teneur en hyoscyamine et en scopolamine d'une population sauvage de Datura stramonium L en Algerie.
Langberg, "Treatment of pyridostigmine-induced AV block with hyoscyamine in a patient with myasthenia gravis," Journal of Cardiovascular Electrophysiology, vol.
Although the active ingredients in Nitroglycerin and Hyoscyamine ER had been present in many products on the market, in the late 1990s the US Food and Drug Administration (FDA) took measures that made the drugs ineligible for reimbursement by government health care programmes.
Distribution of hyoscyamine and scopolamine in Datura stramonium.
* Gastrointestinal antispasmodics (belladonna alkaloids, clidinium, dicyclomine, hyoscyamine, propantheline)
The active compounds are several alkaloids, primarily hyoscyamine. They may be extracted in great quantities from the root by soaking or boiling in wine.
The three most commonly used anticholinergic medications to treat the death rattle in the dying patient are hyoscine hydrobromide (Scopolamine[R]), hyoscyamine sulfate (Levsin[R]), and glycopyrrolate (Robinul[R]) (see Table 2).
Treatments for diarrhea-predominant IBS include dicyclomine and hyoscyamine, and if the diarrhea is accompanied by prominent pain, tricyclic antidepressants may be helpful.
Interventions for cancer-related Dyspnea Recommended for Practice Immediate-release oral or parenteral opioids Likely to Be Effective If the patient has weeks, months, or years to live * Temporary ventilator support * Oxygen therapy * Benzodiazepines for anxiety If the patient is dying Scopolamine, hyoscyamine, or atropine to reduce secretions * Oxygen therapy * Sedation as needed Discontinue fluid support and consider low-dose diuretics Effectiveness Not Established Pharmacologic * Extended-release morphine * Midazolam plus morphine * Nebulized fentanyl, furosemide, lignocaine, or opioids * Supplemental oxygen Nonpharmacologic * Acupuncture * Cognitive-behavioral approach Note.
The alkaloids in mandrake are hyoscyamine C17H 23O3N (scopoletin 2500-3500 ppm), hyoscine C17H 21O4N (scopolamine 30-50 ppm), atropine [C.sub.17][H.sub.23][O.sub.3]N (10-20 ppm) and small quantities of mandragorine that is only found in the root (Ramoutsaki et al.
Antispasmodic and Hyoscyamine (Levsin, Levbid) Dry mouth, blurred