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Placing of a hydroxyl group on a compound in a position where one did not exist before.
References in periodicals archive ?
Targeting of HIF-[alpha] lpha to the von Hippel-Lindau ubiquitylation complex by [O.sub.2] -regulated prolyl hydroxylation. Science 2001; 292: 468-472, doi: 10.1126/science.
Yang et al., "HIFa targeted for VHL-mediated destruction by proline hydroxylation: implications for [O.sub.2] sensing," Science, vol.
Cholecalciferol administration as a potential hydroxylation substrate and precursor of vitamin D-hormone partially or completely attenuated diabetes-induced abnormalities in the vitamin D-endo/para/autocrine system.
Targeting of HIF-[alpha] to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 2001;292:468-72.
Three MN-18 metabolites (M4, M7, and M13) were observed with naphthalene hydroxylation. They displayed [[M + H].sup.+] at m/z 374.1870, which is 15.9937 Da (+O) larger than that of MN-18; they also shared almost the same fragments, m/z 145.0390 and 215.1171, which were observed in MN-18, suggesting naphthalene hydroxylation instead of on the N-pentyl indazole moiety.
To validate the physiological significance of our hypothesis that Cys oxidation and Pro hydroxylation of TRPA1 proteins underlie their [O.sub.2]-sensing function of TRPA1, it is essential to understand how these protein modifications are reversed, because rapid on/off responses are important attributes of acute [O.sub.2] adaptation.
As the helical structures existed in chiral liquid crystals [14-16] and charged compounds could adjust surface charge of NF membranes, the chiral mesogenic compound and the charged compounds were grafted to chitosan through hydroxylation to provide the change of the structure and the surface charge, hence performance of the NF membrane [17-19].
Ti[O.sub.2] is one of the most typical oxides of surface hydroxylation, while the surface hydroxylation of Ti[O.sub.2] as the semiconductor material is complex with various hydroxyl groups.
In mammals, VitC-dependent oxygenases catalyze the hydroxylation of DNA, peptides/proteins, and lipids as well as a wide variety of small molecules.
In essence, transcriptional expression has been reviewed, but there is another kind of gene regulation that involves epigenetic mechanisms such as methylation, acetylation, histone ubiquitination, or DNA methylation and hydroxylation. In this regard, to explore the role of these mechanisms on the regulation of hCYP1A1 expression studies were conducted using the DNMTs inhibitor, 5-aza-2-deoxycytidine (5AzadC), and HDACs inhibitors, trichostatin A (TSA) and sodium butyrate.
Moreover, due to the mutation in VKORC1, vitamin K cannot be activated through hydroxylation and no coagulation occurs.
Vitamin C is necessary for multiple hydroxylation reactions, including hydroxylation of proline and lysine in collagen synthesis, beta-hydroxybutyric acid in carnitine synthesis, and dopamine-beta-hydroxylase in catecholamine synthesis.