brasiliensis which shows almost 60 % homology in its amino acid sequence to the patatin from potato tuber also exhibits a nonspecific lipid acyl hydrolase
activity  that catalyze the cleavage of fatty acids from membrane lipids including phospholipids, lysophospholipids, galactolipids, and mono and diacylglycerols.
The crystal structure of endoglucanase CelA, a family 8 glycosyl hydrolase
from Clostridium thermocellum.
Abide's drug discovery platform provides a great opportunity to fully explore serine hydrolase
inhibition, an important yet underexplored area of chemistry with applications in treating a number of diseases.
In a new study the researchers show the new compounds powerfully and selectively block the activity of a large and diverse group of enzymes known as "serine hydrolases
The description of the substrate mapping of new hydrolases
from thermophiles highlights an interesting area for the application of high-throughput screening.
Probing the active sites of butyrylcholinesterase and cholesterol esterase with isomalathion: conserved stereoselective inactivation of serine hydrolases
structurally related to acetylcholinesterase.
A classification of glycosyl hydrolases
based on amino acid sequence similarities, Biochemical Journal.
He has been Professor for Biotechnology at the TU Hamburg-Harburg, Germany, since 1986, focusing his research on fundamentals of equilibrium and kinetically controlled reactions catalyzed by free and immobilized hydrolases
, the production, post-translational processing and purification of penicillin amidases and serine peptidases by affinity chromatography, as well as fundamentals of mass transfer in chromatography and enzyme technology.
About Serine Hydrolases
The large family of serine hydrolases
are validated but largely under explored as drug targets.
Specific areas of his research interest are enzymatic amidation reactions with hydrolases
, enzymatic chemoselective transformations on natural products, biotransformations with oxynitrilases and oxidoreductases, and chiral recognition with azamacrocycles.
Within the scope of this invention, both active RNA species (such as ribozymes and interfering RNAs) and enzymes (such as kinases, hydrolases
, and transferases) may be produced during commercial manufacturing to control plant genes to produce a product with desirable biochemical properties.
This toolbox is constantly expanding and includes all major classes of catalytic activities that are relevant for fine chemistry such as esterases, nitrilases, nitrile hydratases, amidases, epoxyde hydrolases
, oxydo-reductases and many other ones" said Daniel Dupret, Chairman and CEO of Proteus.