hydrazinolysis

hy·dra·zi·nol·y·sis

(hī'dră-zi-nol'i-sis),
Cleavage of chemical bonds by hydrazine; applied in protein and nucleic acid degradations.
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Interestingly, the reported findings revealed that the hydrazinolysis of pyrimidine-2(1H)-one (7a), 4-methylpyrimidin-2(1H)-one (7b), or 4,6-dimethylpyrimidin-2(1H)-one (7c) resulted in the formation of 1H-pyrazole (8a), 3-methyl-1H-pyrazole (8b) and 3,5-dimethyl-1H-pyrazole (8c), respectively, in addition to urea (la) in each case (Figure 2) [40].
Sequential hydrazinolysis of carbamate (3e) and condensation with a variety of aldehydes and ketones (5a-d) afforded the corresponding semicarbazones (6a-d).
Goettingen, Germany, November 19, 2015 --(PR.com)-- Hydrazinolysis is a traditional method for O-glycan release from glycoproteins.
(1984) Comparative study of the oligosaccharides released from baby hamster kidney cells and their polyoma transformant by hydrazinolysis. J.
The key intermediates in the present study are 1,[omega]-bis[4-(hydrazinecarbonyl)phenoxy]alkanes 1-3, they were prepared from the appropriate 1,[omega]-bis(4-methoxycarbonylphenoxy)alkanes by their hydrazinolysis with hydrazine monohydrate [24].
Alternatively, a chemical cleavage method, such as hydrazinolysis or (non)reductive [beta]-elimination may be useful.
Hydrazinolysis of 9 afforded 5-hydrazino-4-(4-methoxyphenyl)-3,7-dimethyl-1,4-dihydropyrazolo[4',3' :5,6]pyrano[2,3-d]pyrimidine 10.
Santonic acid 3 was then converted into its acyl imidazole derivative 4 followed by hydrazinolysis to give santonic carbohydrazide 5 which was further converted into santonic-1,3,4- oxadiazole-2-thiol 6.
Saccharide chains of N-glycans were released by hydrazinolysis, and labeled with 2-aminopyridine.
The synthetic pathway for the titled compounds was achieved starting with 1,[omega]-bis[4-(hydrazinecarbonyl)phenoxy]alkanes 1-3, they were prepared from the appropriate 1,[omega]-bis(4-methoxycarbonylphenoxy)alkanes by their hydrazinolysis with hydrazine monohydrate [25].
Various studies of the carbohydrate structure of hCG[beta]cf using a combination of immunoaffinity, gel-filtration, and ion-exchange chromatography, glycosidase digestion, hydrazinolysis, and periodate oxidation have been reported (22-26).
2,3-Dihydro-1H-imidazo[1,2-b]pyrazoles 112 and 113 were prepared by hydrazinolysis with 2,4-dinitrophenylhydrazine of ethyl 2-(1-(benzylideneamino)imidazolidin-2-ylidene)-2-nitroace tate 110 which was conveniently prepared from ethyl nitroacetate and N-benzylidene-2-(methylthio)-4,5 dihydro-1H-imidazol-1-amine 109 as described in Scheme 24 [52].