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Related to hydrazide: hydrazine, hydrochlorothiazide, Hydrazone


An organic compound of the general formula RCO-NHNH2; an acyl derivative of hydrazine.
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However, while preparing the compound 5, we have taken 4-nitrobenzohydrazide in place of benzoic acid hydrazide, and hence only the spectral and analytical data of chromophore b are given below.
Yellow solid; Yield: 70%; MP: 299-300[degrees]C; IR ([v.sub.max] [cm.sup.-1]): 3333, 3271, 3213 (N-H), 3080 (=C-H stretching), 1712 (C=O), 1680 (C=O hydrazide), 1614 (C=N), 1564, 1489, 1431, 1411 (C=C, N[O.sub.2], N-H, C-N), 1261 (C-F), 890 (=C-H).
Methionine acid hydrazide (3c): Rf=0.38(CH[Cl.sub.3]); yield 87%; mp104-105[degrees]C; IR (KBr v max[cm.sup.-1]): 3419 (N-H), 2923 (C-H), 1685 (C=O), 1112 (C-N), 619 (C-S-C).
A mixture of hydrazide 7 (3.25 g, 0.01 mole) and formic acid (30 ml) was heated for 24 h (TLC) under reflux.
1.0 mmol of Hydrazide (compound-3) obtained in the previous step was treated with 1.0 mmol of each aldehyde in absolute ethanol (10 ml), 1-2 drops of glacial acetic acid were added and reflux the mixture with continuous stirring for 4-5 h.
The synthetic strategy for the synthesis of imines 8a-g has been described in the Scheme 3, involves reaction of acid hydrazide 1 with thiosemicarbazide to give first on a product it is 1-((5-amino-1,3,4-thiadiazol-2-yl)methyl)-3H-benzo[f]chromen-3-one 7, which is considered as starting material for the synthesis of imines 8a-f and 8g by its reaction with substituted aldehydes or isatin as shown in Scheme 3.
Therefore, an easy, rapid, low-cost, and low-toxic method for quantifying hydrazide groups on magnetic carriers based on bicinchoninic acid (BCA) is needed.
This reaction proceeds through the formation of nonisolable intermediate carbohydrazide 11a-11h at C5 followed by nucleophilic attack of -N[H.sub.2] of hydrazide on [sp.sup.2] C6 rather than the [sp.sup.3] C4 to give the ring opening adducts 12a-12h which produce pyrazole l3 as final product in addition to arylidene of urea/thiourea 14a-14h as nonisolable intermediate.
Equimolar quantities (0.03 moles) of appropriate Isatin a1 and Diclofenac hydrazide III were dissolved in 20 ml of ethanol and refluxed for 6 hours in the presence of 5 drops of glacial acetic acid.
It involved synthesis of compound V (the basic triazole nucleus) via conversion of carboxylic acid into ester (Compound II), hydrazide (Compound III) and dithiocarbazate salt (Compound IV).