: US appearance during in utero evolution.
Zika Virus Infection and Stillbirths: A Case of Hydrops Fetalis, Hydranencephaly
and Fetal Demise.
The toddler, who is being treated at the Philippines Children's Medical Center in Pasig, a city in the metropolitan district of Manila, is fighting to survive hydranencephaly
that doesn't allow the brain to develop and can cause disability, intellectual problems, seizures and vision problems. The condition is incurable and treatment involves using a tube to drain fluid out of the skull.
Zika/associated birth defects include selected congenital brain anomalies (intracranial calcifications; cerebral atrophy; abnormal cortical formation; corpus callosum abnormalities; cerebellar abnormalities; porencephaly; hydranencephaly
; ventriculomegaly/hydrocephaly); selected congenital eye anomalies (microphthalmia or anophthalmia; coloboma; cataract; intraocular calcifications; chorioretinal anomalies involving the macula, excluding retinopathy of prematurity; and optic nerve atrophy, pallor, and other optic nerve abnormalities); and/or microcephaly at birth (birth head circumference <3rd percentile for infant sex and gestational age based on INTERGROWTH/21st online percentile calculator [http://intergrowth21.ndog.ox.ac.uk/]).
This association was demonstrated in a report from Salvador, Brazil, which showed a fetus miscarriage (32nd week) with microcephaly, hydranencephaly
, intracranial calcifications and destructive lesions of posterior fossa.
The study showed the baby's brain was absent, a condition known as hydranencephaly
. Instead of tissue, the brain cavities were filled with fluid.
It was during their 20-week scan that the couple found out that Alice had hydranencephaly
. The condition means Alice's brain isn't fully formed and she is not expected to live beyond childhood.
Two cases of hemifacial microsomia where there was evidence of carotid artery occlusion (28) and a case where the subject lacked an internal carotid artery and showed subsequent facial defects and unilateral hydranencephaly
(29) have been reported.
Results Out of 11,500 pregnant women, CNS anomalies were detected in 48 cases.They included hydrocephalus in 21(43.8%) anencephaly in 11(22.9%), spina bifida in 8(16%), 02 each (4.1%) with encephalocele, arachnoid cysts, hydranencephaly
and 01 each with exencephaly and holoprosencephaly.
Morphogenesis of hydranencephaly
and other intracranial malformations in progeny of pregnant ewes infected with pestiviruses.
(1) Cerebral damage can be severe, as cases of hydranencephaly
with arterial and venous malformations have been reported.