hydralazine


Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.
Related to hydralazine: labetalol

hydralazine

 [hi-dral´ah-zēn]
an antihypertensive agent and vasodilator, administered orally, intramuscularly, or intravenously as the hydrochloride salt in treatment of peripheral vascular disease, essential and early malignant hypertension, thrombophlebitis, and other conditions in which dilation of blood vessels of the extremities is desired. Dosage is adjusted to the individual patient's response. blood pressure should be checked frequently, especially during parenteral administration. Side effects are rare with therapeutic doses, but the drug must be administered with caution to patients with coronary artery disease, advanced kidney damage, and existing or incipient stroke syndrome.

hydralazine

(hī-drăl′ə-zēn′)
n.
An antihypertensive drug, C8H8N4.

hydralazine

Therapeutics A vasodilator which, with isosorbide dinitrate, is a 2nd line therapy in Pts with CHF for whom ACE inhibitors are contraindicated. See Congestive heart failure.

hydralazine

A drug that causes arteries to widen (vasodilatation) and can be used as an adjunct to the treatment of high blood pressure (HYPERTENSION) and moderate degrees of HEART FAILURE. It is seldom used alone. The drug is on the WHO official list. A brand name is Apresoline.
References in periodicals archive ?
Because both hydralazine and nifedipine are associated with tachycardia, it is recommended that these agents not be used in patients with a heart rate above 105-110 beats per minute (bpm).
Patients as initiated on hydralazine plus nitrates formed one arm and those who were being managed without them but on conventional anti-failure therapy formed the other arm.
All the patients were exposed to hydralazine, but the majority of these patients were exposed for less than 12 months (57%).
Most cases describing a DILE syndrome by hydralazine entail a positive ANA, and while negative ANA has been reported, it is a rare manifestation.
A number of different analytical procedures have been developed for the determination of hydralazine from pharmaceutical preparations and biological fluids including titrimetry [1-5], spectrophotometry [6-10], spectroflorometry [11], electrochemical at preanodised screen printed carbon electrode [12], electrochemical [13-14], high performance liquid chromatography [15-17] and gas chromatography (GC) [18-20].
Past medical history included mild persistent asthma treated with albuterol and budesonide-formoterol, postpartum hypertension treated with hydralazine 10 mg PO every 8 hours and chlorthalidone 25 mg PO daily, environmental allergies treated with cetirizine as needed, gastroesophageal reflux disease treated with esomeprazole, prolactinoma treated with cabergoline, and irritable bowel syndrome.
The instigating drug in this case was hydralazine. Hydralazine was discontinued and the patient was started on colchicine and prednisone which was to be tapered gradually.
4-HNE-Induced Tube Formation Is Blocked by Hydralazine (Hdz) and Bisvanillyl-Hydralazone (BVH).
The study included hundred patients with severe gestational hypertension [greater than or equal to]160/110 mmHg, randomly assigned to two groups (one given intravenous hydralazine and the other oral nifedipine) to achieve a blood pressure (BP) of [?]150/100 mmHg.
Effects of nitrates and hydralazine in heart failure: Clinical evidence before the African American Heart Failure Trial.
A month before last year's cardiac cath, hydralazine had been added to her medications, and now her calcium channel blocker was switched to atenolol, a beta blocker selective for beta-1 adrenergic receptors, which primarily affects pulse.
Objective: To compare the efficacy of intravenous hydralazine and intravenous labetalol for acutely lowering blood pressure in pregnancy.