To unambiguously prove that the OH group was consumed by the NCO, the product was heated overnight at 60[degrees]C in an open scintillation vial and monitored for the formation of hydantoin
The first-generation AEDs known to cause birth defects and other developmental toxicities include the hydantoins
(ethotoin [Peganone], fosphenytoin [Cerebyx], mephenytoin [Mesantoin], and phenytoin [Dilantin]), phenobarbital, primidone (Mysoline), carbamazepine (Tegretol), and valproic acid derivatives (Depakene, Depakote).
Children with fetal hydantoin
syndrome typically show multiple symptoms, including disorders of growth and of mental development, dysmorphic craniofacial features, and hypoplasia of the nails and distal phalanges.
There are five classes of agents typically used to control seizures: hydantoins
, barbiturates, benzodiazepines, succinamides and diones.
wheel UR-1100 Hydantoin
266 No UR-1100 Triazine 285 No L-42/Caytur Hydantoin
6 Yes L-42/Caytur Triazine 20 Yes
The 2-(2-pyridyl) cycloalkanones were yellow to orange oils and were characterized by conversion into hydantoin
derivatives (Table 1) (Henze and Speer, 1942).
Phenytoin is associated with fetal hydantoin
syndrome, typified by changes in the finger tips, hypoplasia of nails, a broad nasal bridge, a wide distance between the eyes, and developmental delay.
These 4-alkyl-2-(2-pyridyl)cyclohexanones were yellow to orange oils and were characterized by conversion into hydantoin
Tenders are invited for : lactones, neog, heterocyclic compounds only hetero-atom (s) of nitrogen with the structure noncondensable pirazynove ring, pyrimidine ring or ring piperazolne phenothiazine ring system not further condensation; hydantoin
and its derivatives; sulphonamides (narcotic and psychotropic drugs)
Glydant Plus (liquid) (Lonza) (DMDM hydantoin
In humans, the use of anticonvulsants during pregnancy has been associated with a number of defects and malformations, which collectively are referred to as fetal hydantoin
syndrome, and include microcephaly and intellectual impairment.
In addition, 1% of epileptic women treated with valproic acid during pregnancy will have a baby with neural tube defects, and 5%-10% of fetuses exposed to hydantoin
will have fetal hydantoin
syndrome, which includes microcephaly growth deficiency developmental delays and mental retardation, dysmorphic craniofacial features, and hypoplasia of nails and distal phalanges.