hydantoin


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hy·dan·to·in

(hī-dan'tō-in),
2,4-Imidazolidinedione; derived from urea or from allantoin; the NH-CH2-CO group is prototypical of α-amino acids. Hydantoin derivatives are formed by the reaction of phenylisothiocyanate or phenylisocyanate and a polypeptide.
Synonym(s): glycolylurea

hydantoin

[hīdan′tō·in]
any one of a group of anticonvulsant medications, chemically and pharmacologically similar to the barbiturates, that acts to limit seizure activity and reduce the spreading of abnormal electrical excitation from the focus of the seizure. A primary hydantoin in the management of almost all forms of epilepsy is phenytoin, formerly known as diphenylhydantoin. Frequent determination of the blood concentration of hydantoin is necessary.

hy·dan·to·in

(hī-dan'tō-in)
A crystalline heterocyclic compound derived from urea or from allantoin; the NH-CH2-CO group is prototypical of α-amino acids.

hydantoin

(hī-dăn′tō-ĭn)
A colorless base, glycolyl urea, C3H4N2O2, derived from urea or allantoin.
References in periodicals archive ?
To unambiguously prove that the OH group was consumed by the NCO, the product was heated overnight at 60[degrees]C in an open scintillation vial and monitored for the formation of hydantoin rings (Fig.
The first-generation AEDs known to cause birth defects and other developmental toxicities include the hydantoins (ethotoin [Peganone], fosphenytoin [Cerebyx], mephenytoin [Mesantoin], and phenytoin [Dilantin]), phenobarbital, primidone (Mysoline), carbamazepine (Tegretol), and valproic acid derivatives (Depakene, Depakote).
Children with fetal hydantoin syndrome typically show multiple symptoms, including disorders of growth and of mental development, dysmorphic craniofacial features, and hypoplasia of the nails and distal phalanges.
There are five classes of agents typically used to control seizures: hydantoins, barbiturates, benzodiazepines, succinamides and diones.
wheel UR-1100 Hydantoin 266 No UR-1100 Triazine 285 No L-42/Caytur Hydantoin 6 Yes L-42/Caytur Triazine 20 Yes
The 2-(2-pyridyl) cycloalkanones were yellow to orange oils and were characterized by conversion into hydantoin derivatives (Table 1) (Henze and Speer, 1942).
Phenytoin is associated with fetal hydantoin syndrome, typified by changes in the finger tips, hypoplasia of nails, a broad nasal bridge, a wide distance between the eyes, and developmental delay.
These 4-alkyl-2-(2-pyridyl)cyclohexanones were yellow to orange oils and were characterized by conversion into hydantoin (Fig.
Tenders are invited for : lactones, neog, heterocyclic compounds only hetero-atom (s) of nitrogen with the structure noncondensable pirazynove ring, pyrimidine ring or ring piperazolne phenothiazine ring system not further condensation; hydantoin and its derivatives; sulphonamides (narcotic and psychotropic drugs)
Glydant Plus (liquid) (Lonza) (DMDM hydantoin (and) 0.
In humans, the use of anticonvulsants during pregnancy has been associated with a number of defects and malformations, which collectively are referred to as fetal hydantoin syndrome, and include microcephaly and intellectual impairment.
In addition, 1% of epileptic women treated with valproic acid during pregnancy will have a baby with neural tube defects, and 5%-10% of fetuses exposed to hydantoin will have fetal hydantoin syndrome, which includes microcephaly growth deficiency developmental delays and mental retardation, dysmorphic craniofacial features, and hypoplasia of nails and distal phalanges.