hydantoin


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hy·dan·to·in

(hī-dan'tō-in),
2,4-Imidazolidinedione; derived from urea or from allantoin; the NH-CH2-CO group is prototypical of α-amino acids. Hydantoin derivatives are formed by the reaction of phenylisothiocyanate or phenylisocyanate and a polypeptide.
Synonym(s): glycolylurea

hydantoin

[hīdan′tō·in]
any one of a group of anticonvulsant medications, chemically and pharmacologically similar to the barbiturates, that acts to limit seizure activity and reduce the spreading of abnormal electrical excitation from the focus of the seizure. A primary hydantoin in the management of almost all forms of epilepsy is phenytoin, formerly known as diphenylhydantoin. Frequent determination of the blood concentration of hydantoin is necessary.

hy·dan·to·in

(hī-dan'tō-in)
A crystalline heterocyclic compound derived from urea or from allantoin; the NH-CH2-CO group is prototypical of α-amino acids.

hydantoin

(hī-dăn′tō-ĭn)
A colorless base, glycolyl urea, C3H4N2O2, derived from urea or allantoin.
References in periodicals archive ?
Urea-based ASPs were not detected as evidenced by the lack of hydantoin ring formation upon heating the NCO/AE product.
Anticonvulsants, particularly the hydantoins and barbiturates, are related to hemorrhagic disease of the newborn, so adequate doses of vitamin K should be administered to newborns exposed to AEDs in utero.
The absorption, distribution and elimination of the hydantoins are not equivalent.
wheel UR-1100 Hydantoin 266 No UR-1100 Triazine 285 No L-42/Caytur Hydantoin 6 Yes L-42/Caytur Triazine 20 Yes
The 2-(2-pyridyl) cycloalkanones were yellow to orange oils and were characterized by conversion into hydantoin derivatives (Table 1) (Henze and Speer, 1942).
The first-generation AEDs known to cause birth defects and other developmental toxicities include the hydantoins (ethotoin [Peganone], fosphenytoin [Cerebyx], mephenvtoin [Mesantoin], and phenytoin [Dilantin]), phenobarbital, primidone (Mysoline), carbamazepine (Tegretol), and valproic acid derivatives (Depakene, Depakote).
Hanson & Smith (1975) also described the fetal hydantoin syndrome that includes: intra and extrauterine growth retardation, mental impairment, congenital heart lesions, facial dysmorphisms and limb anomalies.
Phenytoin is associated with fetal hydantoin syndrome, typified by changes in the finger tips, hypoplasia of nails, a broad nasal bridge, a wide distance between the eyes, and developmental delay.
These 4-alkyl-2-(2-pyridyl)cyclohexanones were yellow to orange oils and were characterized by conversion into hydantoin (Fig.
Limited Tenders are invited for N,N - Diglycidyl -5 -5 - Hydantoin As Per Specn.
Commonly implicated drugs are cotrimoxazole, sulphonamides, tetracyclines, isoniazide, hydantoin, carbamazepine barbiturates, phenothiazines, etc.