hyaluronidase


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Related to hyaluronidase: hyaluronic acid

hyaluronidase

 [hi″ah-lu-ron´ĭ-dās]
1. an enzyme that catalyzes the hydrolysis of hyaluronic acid, the “cement material” of connective tissues; it is found in human testes, as well as in leeches, snake venom, and spider venom, and is produced by various pathogenic bacteria, enabling them to spread through tissue.
2. a preparation derived from the secretion of mammalian testes, used to promote absorption and diffusion of solutions injected subcutaneously. When it is mixed with fluids administered subcutaneously, absorption is more rapid and less uncomfortable. This is especially valuable when large amounts of fluid must be given by hypodermoclysis instead of intravenously. The hyaluronidase should be dissolved just before it is used and usually is injected with the first portion of the fluid to be given. Hyaluronidase should not be given in areas where there is infection. Since it hastens absorption, it must be given with caution when administered with toxic drugs, as a toxic reaction can occur rapidly.

hy·a·lu·ron·i·dase

(hī'ă-lū-ron'i-dās),
1. Term applied loosely to hyaluronate lyase, hyaluronoglucosaminidase, and hyaluronoglucuronidase, one or more of which are present in sperm, the testes, and other organs, bee and snake venoms, type II pneumonococci, and certain hemolytic streptococci. Synonym(s): diffusing factor, Duran-Reynals permeability factor, Duran-Reynals spreading factor, invasin, spreading factor
2. A soluble enzyme product prepared from mammalian testes; it is used to increase the effect of local anesthetics and to permit wider infiltration of subcutaneously administered fluids, is suggested in the treatment of certain forms of arthritis to promote resolution of redundant tissue, is used to speed the resorption of traumatic or postoperative edema and hematoma, is used in combination with collagenase to dissociate organs, such as liver and heart, into viable cell suspensions, and in histochemistry is used on tissue secretions to verify the presence of hyaluronic acid or chondroitin sulfates.

hyaluronidase

/hy·al·uron·i·dase/ (hi″ah-ldbobr-ron´ĭ-dās) any of three enzymes that catalyze the hydrolysis of hyaluronic acid and similar glycosaminoglycans, found in snake and spider venom, in mammalian testicular and spleen tissue, and produced by various pathogenic bacteria, enabling them to spread through tissues; a preparation from mammalian testes is used to aid absorption and dispersion of other injected drugs and fluids, for hypodermoclysis, and for improving resorption of radiopaque media.

hyaluronidase

(hī′ə-lo͝o-rŏn′ĭ-dās′, -dāz′)
n.
An enzyme that catalyzes the breakdown of hyaluronic acid in the body, thereby increasing tissue permeability to fluids. Also called spreading factor.

hyaluronidase

[hī′əlyoo͡ron′ədās]
an enzyme that hydrolyzes hyaluronic acid, a component of the extracellular matrix.
indications It is prescribed to increase the absorption and dispersion of parenteral drugs that have extravasated (e.g., vesicant chemotherapeutics), for hypodermoclysis, and for improvement of resorption of radiopaque agents.
contraindications Acute inflammation, infection, or known hypersensitivity to this drug prohibits its use.
adverse effect The most serious adverse effect is hypersensitivity.

hyaluronidase

(1) Hyaluronoglucosaminidase, EC 3.2.1.35.
(2) Hyaluronoglucuronidase, EC 3.2.1.36.
(3) Hyaluronate lyase, EC 4.2.2.1.

hyaluronidase

An enzyme that breaks down proteins holding tissue planes together. Its use assists in the dispersal of tissue fluids or injected drugs. A brand name is Hyalase.

hyaluronidase

an enzyme present in snake venom and bacteria that catalyses the hydrolysis of hyaluronic acid, thus making it ineffective in stopping the spread of invading microorganisms and other toxic substances.

Duran-Reynals,

Francisco, U.S. bacteriologist, 1899-1958.
Duran-Reynals permeability factor - a soluble enzyme product prepared from mammalian testes. Synonym(s): hyaluronidase

hy·a·lu·ron·i·dase

(hī'ă-lū-ron'i-dās)
Soluble enzyme product prepared from mammalian testes; used to increase the effect of local anesthetics and to permit wider infiltration of subcutaneously administered fluids, is suggested in the treatment of forms of arthritis to promote resolution of redundant tissue.

hyaluronidase (hī´əlyooron´ədās),

n an enzyme that produces hydrolysis of hyaluronic acid, the cementing substance of the tissues. Produced by certain pathogenic bacteria and also formed by sperm.

hyaluronidase

an enzyme that catalyzes the hydrolysis of hyaluronic acid, the 'cement material' of connective tissues; it is found in leeches, snake and spider venom, in testes, and is produced by various pathogenic bacteria, enabling them to spread through tissue. A preparation from mammalian testes is used to promote absorption and diffusion of solutions injected subcutaneously. When hyaluronidase is mixed with fluids administered subcutaneously, absorption is more rapid and less uncomfortable. Hyaluronidase should not be given in areas where there is infection. Since it hastens absorption, it must be given with caution when administered with toxic drugs, as the toxic reaction can occur very rapidly.
References in periodicals archive ?
Only one of the five patients required hyaluronidase to remove excessive filler.
Notably, many case reports of adverse events have been published in the literature regarding the use of animal-derived hyaluronidase with local anesthetic ophthalmic blocks.
Hyaluronidase in tissue invasion, Invasion metastasis.
5 ml 25 mg/ml) and hyaluronidase (1500 IU) at weekly interval for 22 wk and group 'B' were treated by a combination of triamcinolone acetonide, 10 mg/ ml and hyaluronidase (1500 IU) at 15 days interval for 22 wk, i.
In addition, the effects of glycerol as a cryoprotective agent on goat sperm and release of the hyaluronidase enzyme were examined.
As a recombinant protein, HYLENEX represents an advanced and more sustainable supply of hyaluronidase, circumventing the quality and supply problems that have historically been associated with animal-derived product," said Gregory Frost, Ph.
SALT LAKE CITY -- Recombinant human hyaluronidase makes it possible to safely hydrate patients subcutaneously with a gravity line feed at flow rates approaching 500 cc/hour, according to a preliminary study presented at the annual meeting of the American Academy of Hospice and Palliative Medicine and the Hospice and Palliative Nurses Association.
Strategies for managing extravasation have not been systematically tested in randomized clinical trials, but one drug, hyaluronidase (Vitrase[R], ISTA Pharmaceuticals, Irvine, CA), has been approved by the U.
Halozyme has received FDA approval for two products: Cumulase, the first and only recombinant human hyaluronidase for cumulus removal in the IVF process, and Hylenex for use as an adjuvant to increase the absorption and dispersion of other injected drugs.