Hyaluronans in the treatment of osteoarthritis of the knee: evidence for disease-modifying activity.
[29,30,35] It is speculated that hyaluronan bind inflammatory mediators, free radicals, removing them from the joint space via lymphatics, thereby reducing cartilage damage.
Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action.
Intraarticular hyaluronan injections in the treatment of osteoarthritis: state-of-the-art review.
The biological action of hyaluronan on human osteoartritic articular chondrocytes: the importance of molecular weight.
Arthroscopic evaluation of potential structure modifying activity of hyaluronan (Hyalgan) in osteoarthritis of the knee.
Long-term effects of intraarticular hyaluronan on synovial fluid in osteoarthritis of the knee.
Ultrastructural findings after intraarticular application of hyaluronan in a canine model of arthropathy.
Reduction of sensory responses to passive movements of inflamed knee joints by hylan, a hyaluronan derivative.
And, for this reason, hyaluronans are used for the viscosupplementation of joints.
Carmona, et al., "Effect of the Administration of an Oral Hyaluronan Formulation on Clinical and Biochemical Parameters in Young Horses with Osteochondrosis," Vet.