In pseudopapillary areas, hyalinized
and thickened vessels were covered by single or multiple layers of uniform cuboidal cells [Figure 1]d.
Microscopically, keloid showed glassy, hyalinized
, homogeneous, brilliantly eosinophilic collagen.
The tumor is composed of a complex, arborizing, and interwoven papillary architecture, usually showing hyalinized
fibrovascular cores (figure 1).
C, Solid papillary carcinoma composed of solid nests of cells with delicate and hyalinized
The papillae show hyalinized
fibrovascular cores and lined by round to polygonal cells with clear to eosinophilic cytoplasm, monomorphic nuclei and eosinophilic nucleoli.
Differential diagnoses for perineal nodular induration Differential diagnosis Histolopathological features Ischemic fasciitis (13-15) Outer fringe of mitotically active fibroblasts and occasional ganglion-like cells and small vessels surrounding a central zone of necrobiosis Cellular angofibrom (*16) Uniformly moderately cellular with plump, bland spindle cells, hyalinized
round, thick and walled vessels may contain adipose tissue Angiomyofibroblastoma-like tumour Alternating hypercellular and of the male genital tract (*17) hypocellular areas with clusters of rounded, epithelioid cells around numerous small vessels Mammary type fibroblastoma (*18) Well-circumscribed, more cellular, and lacks a central zone pattern.
All the biopsies revealed almost similar histopathological features and consisted of necrotic antral mucosa, proliferating fibrous tissue, and bands of hyalinized
collagen with dense chronic lymphoplasmacytic infiltrates with formation of lymphoid follicles and giant cells extending into the subcutaneous fat and septa along with varying stages of granulation tissue (figure 3).
Pathologic evaluation of the ultrasound-guided core biopsy showed a nodular proliferation of uniform, bland ovoid to spindle-shaped cells separated by prominent adipose tissue and hyalinized
collagen bundles, with no significant atypia or mitotic activity (Figure 3).
Microscopically, keloid depicted homogeneous, brilliantly eosinophilic, haphazardly dispersed, glassy, hyalinized
Histopathological study revealed widely hyalinized
fibrotic tissue with spotty hyalinizing necrosis infiltrating adipose tissue and striated muscle tissue (Figures 2a, 2b).
The lumen contained eosinophilic homogenous hyalinized
material with many cholesterol clefts and red blood cells.
Others included, chondromyxoid, osteoid (Fig 4E), lipomatous (Fig 4D) and hyalinized
stroma (Table 4).