huperzine A


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huperzine A

Chinese medicine
An ACE (acetylcholinesterase)-inhibiting sesquiterpene alkaloid found in the plant firmoss (Huperzia serrata). While not FDA-approved for such, it is sold in the US as a memory-enhancing dietary supplement; it is used in traditional Chinese medicine for oedema, fever and blood dyscrasia. Like tacrine, HA increases synaptic acetylcholine by inhibiting acetylcholinesterase; early data suggests that it may have some benefit in patients with Alzheimer's disease, epilepsy and in myasthenia gravis.

Adverse effects
Mild cholinergic effects, as well as dyspnoea, chest pain, rash, pruritus, gastritis, diarrhoea, vomiting, hyperactivity and insomnia.

huperzine A (hōōˑ·pr·zēn),

n a potent alkaloid obtained from the
Huperzia serrata club moss; used to improve memory both in healthy individuals and in those suffering from memory loss. Precaution advised for those with high blood pressure, kidney disease, and liver disease. Self-medication is not advised.
References in periodicals archive ?
BIS-001 is a highly potent form of huperzine A, a synthetic extract of a traditional Chinese medicine with a long history of safe use.
Biscayne Forms Neurotherapeutics Business, Closes USD 3m Venture Financing
Q My sister takes a supplement called huperzine A because she heard it helps preserve memory as you age.
Ask the experts
A Huperzine A is a dietary supplement made from a type of club moss.
Q & A
Q Is huperzine A helpful for people with memory problems?
Ask the doctor
Additionally, the line includes Omega 3 Power, which provides 1,600 mg of omega 3 fatty acids from ultra-purified fish oil; and Brain & Memory Power Boost, which includes N-Acetyl-Cysteine (NAC), phosphatidylserine, huperzine A and acetyl-l-carnitine, vinpocetine and gingko biloba.
Brain Power Basics
Huperzine A (HupA) is a reversible and selective inhibitor of acetylcholinesterase (AChE), and it has multiple targets when used for Alzheimer's disease (AD) therapy.
Huperzine a activates Wnt/B-catenin signaling and enhances the nonamyloidogenic pathway in an Alzheimer transgenic mouse model
The AChE activity was found to be significantly reduced in both the cortex and hippocampus, although this activity was less potent than that of reference inhibitor huperzine A (0.
Huperzia quadnfariata and Huperzia reflexa alkaloids inhibit acetylcholinesterase activity in vivo in mice brain
Huperzine A can also be helpful in people with frequent "senior moments," the age-related gap in mental recall that's common with aging.
This little-known nutrient improves memory, even in people with Alzheimer's disease
Washington, August 26 (ANI): Scientists at Yale University have developed the first practical method to create a compound called huperzine A, which occurs naturally in a species of moss found in China, believed to treat Alzheimer's disease.
Alzheimer's-fighting Chinese herb compound synthesized
com's "Product Review: Supplements for Memory & Cognition Enhancement," which focuses on three ingredients that have shown some promise in improving memory: Ginkgo biloba, huperzine A, and acetyl-L-carnitine.
Adulteration suspected with some 'memory' supplements
Huperzine A is a potent, selective, reversible inhibitor of acetylcholinesterase.
Huperzine A for Alzheimer's disease
The other half includes some familiar substances like DHA (an omega-3 fatty acid found in fish), choline (a type of fat found in many foods, but possibly deficient in some older people), bilberry extract (purported to improve circulation) and huperzine A (a chemical extracted from herbs undergoing testing for use in treating Alzheimer's disease), grape seed extract, and some less familiar herbs like bacopa and vinpocetine.
Looking to improve your memory? Forget pricey Focus Factor
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