huperzine


Also found in: Dictionary.

huperzine

(hoop′ĕr-zēn″),

Hup

An alkaloid present in the Asian herb (Huperzia serrata). This alkaloid inhibits cholinesterases. It has been proposed as a treatment for dementia resulting from Alzheimer disease.
References in periodicals archive ?
Huperzine A, an alkaloid isolated from the Chinese herb Huperzia serrata (Lycopodiaceae), is a reversible, potent and selective AChE inhibitor with a longer duration of action and the ability to cross the blood-brain barrier.
Huperzine A protects C6 rat glioma cells against oxygen-glucose deprivation-induced injury.
Paul Aisen, MD, Director of the ADCS and Principal Investigator for this clinical study, stated, "As we continue to analyze the results, it remains quite clear that this Phase II trial succeeded in demonstrating cognitive enhancement and tolerability with huperzine A treatment in Alzheimer's disease.
Huperzine A attenuates cognitive dysfunction and neuronal degeneration caused by [beta]-amyloid protein (1 -40) in rats.
The trial compared the safety, tolerability and efficacy of either 200 or 400 micrograms of Huperzine A administered orally twice a day for 16 weeks versus placebo.
The trial is comparing the safety, tolerability and efficacy of either 200 or 400 micrograms of Huperzine A administered orally twice a day for 16 weeks versus placebo.
The lycopodium alkaloid huperzine A [9] related to the quinolizidines, is a potent, yet reversible, inhibitor of AChE and is used in China for treating patients with myasthenia gravis and AD.
Our lead product candidate, Huperzine A, is being clinically tested for efficacy in the treatment of Alzheimer's disease and has shown to protect nerve cell death and have longer duration of AChE inhibitory action.
Similarly, huperzine A, a lycopodium alkaloid isolated from Huperzia serrata, has been shown to reduce neuronal cell death caused by oxidative stress (Xiao et al.
Memory Formula contains turmeric acid and huperzine.
saururus containing huperzine A (selagine) (Ayer et al.