huperzine


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huperzine

(hoop′ĕr-zēn″),

Hup

An alkaloid present in the Asian herb (Huperzia serrata). This alkaloid inhibits cholinesterases. It has been proposed as a treatment for dementia resulting from Alzheimer disease.
References in periodicals archive ?
HOW TO TAKE IT: Commonly taken in capsules or powder form, or in capsules of the active ingredient huperzine A on its own.
Huperzine A is an acetylcholinesterase inhibitor with high brain penetration that offers a unique mechanism of action for the treatment of epilepsy.
Moreover, molecular modifications that would allow the establishment of hydrogen interactions with the catalytic residue Ser203 (described for galantamine; Figures 3(c) and 3(d)) and elongation of the molecule that would favor the establishment of additional [pi]-[pi] or cation-[pi] interactions with residues such as Trp86, Trp286, or Tyr337 (described for donepezil and huperzine A; Figures 3(a), 3(b), 3(e), and 3(f)) are foreseen as being important for the AChE inhibitory ability of flavones.
Some structural motives in the biperiden resemble another AChE inhibitor, compound known as huperzine A.
For instance, according to the progress report on new AEDs published as a summary of the Twelfth Eilat Conference (EILAT XII) that took place in Madrid (Spain) in 2014 (Bialer et al., 2015), at least three of the AED candidates in clinical development are herb-derived compounds (cannabidiol, cannabidivarin and huperzine A).
For instance, you can protect the neurotransmitter acetylcholine, which helps in muscle activation, by taking Huperzine A, found in Chinese club moss.
Huperzine A (HupA), a Traditional Chinese Medicine derived from a genus of clubmosses known as Huperzineserrata, is a powerful AChE inhibitor that has been used as an adjunctive treatment for MDD, but no meta-analysis on HupA augmentation for MDD has yet been reported.
brain cells" --not enough evidence to assess possible benefit as medical food Co-Enzyme Q 10, Antioxidant Small trial of Ubiquinone synthetic version: Not effective Coral Calcium Calcium carbonate FDA and FTC filed plus trace complaints against minerals the product for exaggerated claims Curcumin Turmeric Traditional Indian derivative; spice: No clinical Antiinflammatory; trials Antioxidant Gingko Biloba Antioxidant; Anti Traditional Chinese -inflammatory medicine; Small trials and metaanalysis in 199's and 2000's suggested benefit: Phase III trial--no benefit, and GEM (Gingko Evaluation and Memory trial) --no benefit Huperzine A Properties similar Traditional Chinese to cholinesterase medicine (moss inhibitors extract); Small trials ongoing: Alz.
Presently, several referenced natural acetylcholinesterase inhibitors are known, including physostigmine, galantamine, and huperzine A.
Q My sister takes a supplement called huperzine A because she heard it helps preserve memory as you age.
(126-128) Herbal cholinergic support may include phosphatidyl choline, pantothenic acid, huperzine A (from Huperzia serrata), and N-aceytl-L-carnitine.