humoral immunity


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Related to humoral immunity: innate immunity

hu·mor·al im·mu·ni·ty

immunity associated with circulating antibodies, in contradistinction to cellular immunity. The inherent range of activity of antibody specificities is wide but proliferation of antigen-specific B cells occurs rapidly during infections leading to rapid increases in antibody titers with enhanced affinity for the inciting agent, and a more effective and directed response.

humoral immunity

n.
Immunity involving the transformation of B-lymphocytes into plasma cells that produce and secrete antibodies to a specific antigen.

hu·mor·al im·mu·ni·ty

(hyū'mŏr-ăl i-myū'ni-tē)
Immunity associated with circulating antibodies, in contradistinction to cellular immunity.
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HUMORAL IMMUNITY

humoral immunity

The protective activities of antibodies against infection or reinfection by common organisms, e.g., streptococci and staphylococci. B lymphocytes with receptors to a specific antigen react when they encounter that antigen by producing plasma cells (which produce antigen-specific antibodies) and memory cells (which enable the body to produce these antibodies quickly in the event that the same antigen appears later). B-cell differentiation also is stimulated by interleukin-2 (IL-2) secreted by CD4+ T cells and foreign antigens processed by macrophages.

Antibodies produced by plasma B cells, found mainly in the blood, spleen, and lymph nodes, neutralize or destroy antigens in several ways. They kill organisms by activating the complement system; neutralize viruses and toxins released by bacteria; coat the antigen (opsonization) or form an antigen-antibody complex to stimulate phagocytosis; promote antigen clumping (agglutination); and prevent the antigen from adhering to host cells.

Synonym: B-cell–mediated immunity See: illustration; cell-mediated immunity; immunoglobulin
See also: immunity
References in periodicals archive ?
(iii) If [R.sub.1] > 1, then system (1) has an infection equilibrium with humoral immunity of the form [mathematical expression not reproducible].
Bevan, "Cellular and humoral immunity against vaccinia virus infection of mice," The Journal of Immunology, vol.
Assessment of humoral immunity to poliomyelitis, tetanus, hepatitis B, measles, rubella, and mumps in children after chemotherapy.
Postnatal development of bursa of Fabricius in relation to humoral Immunity in Keets.
These results demonstrated that fungal polysaccharides induced humoral immunity response through increasing production of antibody.
The immune system including cellular immunity and humoral immunity will be activated when the defense barrier is destroyed by microorganisms.
Finally, for those with other medical conditions, ACIP still recommends that all immunocompromised males and females aged 9-26 years get a three-dose HPV vaccination at 0, 1-2, and 6 months, but now the language change will read that "Persons who should receive three doses are those with primary or secondary immunocompromising conditions that might reduce cell-mediated or humoral immunity, such as B lymphocyte antibody deficiencies, T lymphocyte complete or partial defects, HIV infection, malignant neoplasm, transplantation, autoimmune disease, or immunosuppressive therapy, since response to vaccination may be attenuated."
The B lymphocytes responsible for humoral immunity produced immunoglobulins which recognized and eliminated extra cellular antigens.
The ImmuneHealth lab also possesses complementary expertise and assays for cellular and humoral immunity that will help support Caprion's efforts to further diversify its services offering in the areas of infectious diseases and vaccine development.
abortus S19 activate humoral immunity and one of its drawbacks is antibody production after vaccination that always problems resulted from it is raised(19).
The production of high-affinity class-switched antibodies is necessary for the clearance of pathogens after infection, for the establishment of long-term humoral immunity and for the effectiveness of vaccines (1).
They also depress antioxidant system and humoral immunity.7,10 SP-D secreted by type II pneumocytes is hypothesised to be associated with pulmonary host defences.