humoral hypercalcemia of malignancy


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humoral hypercalcemia of malignancy

hypercalcemia of malignancy caused by bone resorption mediated by circulating osteoclast-activating factors released from distant tumor cells.
References in periodicals archive ?
Calcium-sensing receptor induces proliferation through p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase but not extracellularly regulated kinase in a model of humoral hypercalcemia of malignancy.
Among eight patients with metastatic bone disease, only one, who developed humoral hypercalcemia of malignancy, had serum Bio-PTH concentrations more than 2 SD below the mean for the healthy controls.
Parathyroid hormone-related protein (PTHrP) was originally isolated from specific cancers as the primary cause of humoral hypercalcemia of malignancy, a paraneoplastic syndrome occurring in humans with a wide variety of malignancies (1).