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factor IX (human)

AlphaNine SD, Immune VH (CA), Mononine

factor IX (recombinant)

BeneFix

factor IX complex

Bebulin VH, Defix (UK), Hipfix (UK), Octaplex (CA), Profilnine SD, Proplex T (heat-treated), Replenine (UK)

Pharmacologic class: Blood modifier

Therapeutic class: Antihemophilic

Pregnancy risk category C

Action

Converts fibrinogen to fibrin, increasing levels of clotting factors

Availability

Powder for injection: Various strengths; units specified on label

Indications and dosages

Factor IX deficiency (hemophilia B or Christmas disease); anticoagulant overdose

Adults and children: Dosage individualized; drug administered I.V. Use following equations to calculate approximate units needed:

Human product-1 unit/kg times body weight (in kg) times desired increase in factor IX level, expressed as percentage of normal

Recombinant product-1.2 units/kg times body weight (in kg) times desired increase in factor IX level, expressed as percentage of normal

Proplex T-0.5 unit/kg times body weight (in kg) times desired increase in factor IX level, expressed as percentage of normal

Off-label uses

• Hepatic dysfunction

• Esophagitis

• Unspecified GI hemorrhage (human product)

Contraindications

• Hypersensitivity to mouse or hamster protein (with BeneFix)

• Fibrinolysis

Precautions

Use cautiously in:

• recent surgery

• pregnant patients

• children younger than age 6 (safety and efficacy not established).

Administration

Give by slow I.V. infusion. Average infusion rate is 100 units (2 to 3 ml)/minute; don't exceed 10 ml/minute.

• If prescribed, administer hepatitis B vaccine before giving factor IX.

• Know that dosage is highly individualized according to degree of factor IX deficiency, patient's weight, and bleeding severity.

• Don't use glass syringe. Don't shake reconstituted solution or mix with other I.V. solutions.

Adverse reactions

CNS: light-headedness, paresthesia, headache

CV: blood pressure changes, thromboembolic reactions, myocardial infarction (MI)

EENT: allergic rhinitis

GI: nausea, vomiting

Hematologic: disseminated intravascular coagulation (DIC)

Respiratory: pulmonary embolism

Skin: rash, flushing, diaphoresis, pruritus, urticaria

Other: altered taste, fever, chills, burning sensation in jaw and skull, pain at I.V. injection site, hypersensitivity reactions including anaphylaxis

Interactions

Drug-drug. Aminocaproic acid: increased risk of thrombosis

Patient monitoring

• Be aware that factor IX complex may transmit hepatitis.

• Closely monitor vital signs during infusion.

Observe for hemolytic reaction. If it occurs, stop infusion, flush line with saline solution, and notify prescriber immediately.

• Monitor I.V. injection site closely.

Monitor coagulation studies closely. Know that drug may cause thromboembolic disorders, including MI and DIC.

Patient teaching

• Inform patient that drug may transmit diseases.

Tell patient to immediately report signs and symptoms of hypersensitivity reaction, including rash, hives, tightness in chest, wheezing, shortness of breath, and swelling of throat or lips.

Advise patient to immediately report unusual bleeding or bruising.

• Caution patient to avoid activities that can cause injury.

• Tell patient to wear medical identification stating that he has a blood-clotting disorder.

• Instruct patient to notify surgeon or dentist of his blood-clotting disorder before surgery or invasive dental procedures.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs mentioned above.

human

(hyo͞o′mən)
n.
A member of the primate genus Homo, especially a member of the species Homo sapiens, distinguished from other apes by a large brain and the capacity for speech.
adj.
Of, relating to, or characteristic of humans: the course of human events; the human race.

hu′man·hood′ n.
hu′man·ness n.

Patient discussion about human

Q. I am a man with breast cancer. Hello friends, you might have heard about breast cancer in women but here I am a man with breast cancer. Is Herceptin licensed to treat me?

A. Hi, what were your symptoms and when did you discover you had breast cancer?

Q. what are the basics products we as a humans, need to have in our diet?

A. A regular healthy diet should be comprised of a 40-50% carbohydrate (bread, rice, etc.), 30-40% protein (dairy, meat, chicken, fish) and 20% fat. Other important ingredients are fruit and vegetables, that contain large amounts of fibers and vitamins.

Q. Is there a difference between a man's diet and a woman's diet? let say for the point of it the weight the same and they are in the same age .

A. no one should have the same exact diet, you need to find what works for you and helps you achieve your goals.

the base of the diet could be the same, for example burn calories then you consume. But other wise, find what works for you.

More discussions about human
References in periodicals archive ?
All of us at Teacher Education Quarterly welcome your feedback and encourage you to continue to promote genuine humanness and caring as well as moral and civic responsibility for all.
This feature--the humanness of God--is what gives Luther's theology its significant character, a character of dynamic reality, of flexibility, of vivacity and change, while on the same solid stable foundation, outside of ourselves, in God alone and his grace and his Word.
But the humanist tradition does not fetishize biological humanness, and human rights do not depend on biological similarity.
One Thought for Colleagues in Public Human Services: The way you see the humanness in others affects the way you treat your clients, employees, advocates, the press, legislators, and family members.
She was sold to a circus owner as a curiosity, and forced into nude public displays in London and Paris, subject to cruel stares and crude comments, exhibited as a zoo animal, desperate to assert her "humanness ...
And within this field there is an interchange between my humanness and its trunkiness ...
By introducing each selection with a "headnote" that discusses the authors in relation to their research, Murray--who had interviewed the scholars on their background and research experiences--underscores the humanness of the historical research process, the importance of persistence, and the role of serendipity.
The resolution, if there is one, then lies in the recognition that the human act of making, though limited by its very humanness, still bears the earmarks of its prototype and cannot, therefore, help but to aspire to divinity.
In the States they don't have anything to do with religion in schools, but I think part of humanness is recognising you have spirit and we try and monitor that side of their lives.'
Profane space leads to a lack of reality; a dismantling of humanness.
(7) The cultural melancholia for "humanness" reflected not a real loss of pre-capitalist subjecthood, but a market-generated desire for a surplus-value attainable outside the transactions of the economy.