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factor IX (human)
factor IX (recombinant)
factor IX complex
Pharmacologic class: Blood modifier
Therapeutic class: Antihemophilic
Pregnancy risk category C
Converts fibrinogen to fibrin, increasing levels of clotting factors
Powder for injection: Various strengths; units specified on label
Indications and dosages
➣ Factor IX deficiency (hemophilia B or Christmas disease); anticoagulant overdose
Adults and children: Dosage individualized; drug administered I.V. Use following equations to calculate approximate units needed:
Human product-1 unit/kg times body weight (in kg) times desired increase in factor IX level, expressed as percentage of normal
Recombinant product-1.2 units/kg times body weight (in kg) times desired increase in factor IX level, expressed as percentage of normal
Proplex T-0.5 unit/kg times body weight (in kg) times desired increase in factor IX level, expressed as percentage of normal
• Hepatic dysfunction
• Unspecified GI hemorrhage (human product)
• Hypersensitivity to mouse or hamster protein (with BeneFix)
Use cautiously in:
• recent surgery
• pregnant patients
• children younger than age 6 (safety and efficacy not established).
☞ Give by slow I.V. infusion. Average infusion rate is 100 units (2 to 3 ml)/minute; don't exceed 10 ml/minute.
• If prescribed, administer hepatitis B vaccine before giving factor IX.
• Know that dosage is highly individualized according to degree of factor IX deficiency, patient's weight, and bleeding severity.
• Don't use glass syringe. Don't shake reconstituted solution or mix with other I.V. solutions.
CNS: light-headedness, paresthesia, headache
CV: blood pressure changes, thromboembolic reactions, myocardial infarction (MI)
EENT: allergic rhinitis
GI: nausea, vomiting
Hematologic: disseminated intravascular coagulation (DIC)
Respiratory: pulmonary embolism
Skin: rash, flushing, diaphoresis, pruritus, urticaria
Other: altered taste, fever, chills, burning sensation in jaw and skull, pain at I.V. injection site, hypersensitivity reactions including anaphylaxis
Drug-drug. Aminocaproic acid: increased risk of thrombosis
• Be aware that factor IX complex may transmit hepatitis.
• Closely monitor vital signs during infusion.
☞ Observe for hemolytic reaction. If it occurs, stop infusion, flush line with saline solution, and notify prescriber immediately.
• Monitor I.V. injection site closely.
☞ Monitor coagulation studies closely. Know that drug may cause thromboembolic disorders, including MI and DIC.
• Inform patient that drug may transmit diseases.
☞ Tell patient to immediately report signs and symptoms of hypersensitivity reaction, including rash, hives, tightness in chest, wheezing, shortness of breath, and swelling of throat or lips.
☞ Advise patient to immediately report unusual bleeding or bruising.
• Caution patient to avoid activities that can cause injury.
• Tell patient to wear medical identification stating that he has a blood-clotting disorder.
• Instruct patient to notify surgeon or dentist of his blood-clotting disorder before surgery or invasive dental procedures.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs mentioned above.
Patient discussion about human
Q. I am a man with breast cancer. Hello friends, you might have heard about breast cancer in women but here I am a man with breast cancer. Is Herceptin licensed to treat me?
Q. what are the basics products we as a humans, need to have in our diet?
Q. Is there a difference between a man's diet and a woman's diet? let say for the point of it the weight the same and they are in the same age .
the base of the diet could be the same, for example burn calories then you consume. But other wise, find what works for you.