humanized


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Related to humanized: Humanized monoclonal antibody

humanized

(hū′mă-nīzd″)
Chemically altered to resemble natural human amino acid sequences. It applies to proteins or polypeptides derived from animals, e.g., mice, that are altered to reduce their antigenic potential.
humanize
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
But now that times have changed, Up Country brings a sense of style with over 120 collar designs and dozens of lifestyle accessories that people love for their pets because it adds humanized personalization.
Incomplete eradication of the native immune system results in the development of lymphomas whereby more advanced humanized models have had much longer lag time and a lower propensity allowing for prolonged longitudinal studies [30].
The researchers conclude that the humanized mouse model is not suitable for studying the human immune response to transplanted stem cells or cells derived from them.
The CYP2A antibody-inhibition data (Figure 1B) further supports these conclusions, and allays any suspicion that the activity difference between the two humanized mouse models was due to contribution by CYP2B6.
According to what is expressed by patients, family members, and nurses participating in the study, when referring to nursing care, it should not be necessary to pin down certain attributes, given that by definition, they are implicit in it and this is precisely the case of the adjective "humanized".
Regardless of the creative concept, the humanized brand will communicate the message, either directly or in a subtle way, that the bank understands its customers as humans, cares about what they are feeling and is committed to meeting their needs.
The researchers discovered that the combination of these two molecules allowed the allogeneic cells to survive in humanized mice without triggering an immune rejection.
The humanized anti-CD19 antibody was constructed using the same human antibody backbone as epratuzumab and veltuzumab, both of which have demonstrated strong safety profiles in a multitude of clinical trials in oncology and autoimmune disorders," commented Cynthia L.
Garcia and colleagues pioneered the humanized "BLT" mouse model, which is created by introducing human bone marrow, liver and thymus tissues into animals without an immune system of their own.
"Having to change programs to perform simple tasks -- such as make a quick calculation or look up a definition -- it breaks your concentration, takes you away from the task at hand, and wastes valuable time," said Aza Raskin, president of Humanized and son of the late Jef Raskin, creator of the Apple Macintosh.