human skin equivalent


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human skin equivalent

Graft made of living human skin grown in a laboratory and used, e.g., to treat leg ulcers in patients with peripheral vascular disease or diabetes mellitus. The graft bonds with healthy tissue in a wound from which necrotic tissue has been removed, improving healing. It is grown from foreskin removed from neonates but also contains bovine (cow) proteins, limiting its use to those with no allergy to these proteins.
Synonym: artificial skin; tissue-engineered skin
See also: equivalent
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Development of a full-thickness human skin equivalent in vitro model derived from TERT-immortalized keratinocytes and fibroblasts.
Non-Animal Models in Dermatological Research
These findings were particularly surprising since we and others have reported that CCL20 can be secreted by keratinocytes and human skin equivalents in an IL-1[alpha]-dependent manner [30, 31] and that the contact allergen nickel sulfate and the contact irritant sodium dodecyl sulfate (SDS) increase CCL20 secretion from human skin equivalents in an IL-1[alpha]-dependent manner [31].
Saliva-Derived Host Defense Peptides Histatinl and LL-37 Increase Secretion of Antimicrobial Skin and Oral Mucosa Chemokine CCL20 in an IL-1[alpha]-Independent Manner
ascertained whether the Marine Complex from Imedeen could variously alter skin morphogenesis in female and male human skin equivalents. Cells were culled from female and male donors between the ages of 30 and 45 years for human skin equivalents that were cultured for 7 or 11 weeks with or without Marine Complex.
Marine ingredients and the skin

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