human placental lactogen


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Related to human placental lactogen: estrogen, HCG, prolactin, human chorionic gonadotropin

lactogen

 [lak´to-jen]
any substance that enhances lactation.
human placental lactogen (HPL) (hPL) a hormone secreted by the placenta, which disappears from the blood immediately after delivery. It has lactogenic, luteotropic, and growth-promoting activity, and inhibits maternal insulin activity during pregnancy.

hu·man pla·cen·tal lac·to·gen (HPL),

lactogen isolated from human placentas and structurally similar to somatotropin; its biologic activity weakly mimics that of somatotropin and prolactin; secreted into maternal circulation; a deficiency of HPL during pregnancy leads to children who undergo abnormal intrauterine and postnatal growth.

human placental lactogen (HPL)

a placental hormone that may be deficient in certain abnormalities of pregnancy. The normal concentrations of this hormone in serum after the fifth week of pregnancy are 0.5 μg/mL and increase to approximately 8 μg/mL at the time of delivery. Also called chorionic somatomammotropin.

human placental lactogen

Chorionic somatomammotropin, hPL, human placental lactogen, human chorionic somatomammotropin A hormone produced during implantation of a fertilized egg, and secreted by the placenta; hPL regulates and coordinates fetal growth and metabolism and maternal metabolism Maternal effects Relative insulin resistance, ↑ circulating free fatty acids; hPL may optimize metabolism of nutrients by the fetus in 1st half of pregnancy; in 2nd half, there is little correlation between hPL levels and fetal well-being; hPL stimulates milk production and breast enlargement, and is somatotopic and luteotropic; urine and plasma HPL levels reflect placental size and are higher in diabetic mothers Ref range Rises during gestation, plateauing at 37 wks at 10 mg/mL; ♂ <0.5 mg/mL; non-pregnant ♀ <0.5 mg/mL; wks of gestation 5-27 <4.6 mg/mL; 28-31 wks, 2.4-6.1 mg/mL; 32-35 wks, 3.7-7.7 mg/mL; 36 wks to term, 5-8.6 mg/mL; hPL is ↓ in postmaturity syndrome, retarded growth, toxemia of pregnancy, threatened abortion; it is ↑ DM, Rh isoimmunization, hydatiform mole, choriocarcinoma Critical value <4 μg/mL after 30 wks gestation

hu·man pla·cen·tal lac·to·gen

(hyū'măn plă-sen'tăl lak'tŏ-jen)
Any agent to stimulate human milk production that has been isolated from human placentas; its biologic activity mimics that of somatotropin and prolactin; secreted into maternal circulation; deficiency during pregnancy leads to abnormal intrauterine and postnatal growth.
Compare: bioregulator
Synonym(s): chorionic growth hormone-prolactin, human chorionic somatomammotropic hormone, placental growth hormone.
References in periodicals archive ?
1A) and a placenta-specific mRNA, human placental lactogen (hPL) mRNA (10) (data not shown), were detected in the maternal plasma aliquots without formaldehyde treatment but in none of the paired aliquots treated with formaldehyde.
The understanding that fetal RNA in maternal plasma is predominantly placental in origin with easy and reliable detection of human placental lactogen (hPL) [3] mRNA in all pregnancy stages is in accordance with the fact that the major cell type circulating in the maternal blood is of trophoblastic, in particular extravillus, origin (5).
trophoblast-produced human placental lactogen or placental growth hormones) may open new opportunities for detecting and monitoring aberrant or differentially expressed genes.
Like hCG, inhibin A, and a range of other secretory products of the placenta, including human placental lactogen, 5N1 (s1-glycoprotein of pregnancy), and progesterone, cell-free fetal DNA in the maternal circulation is increased in Down syndrome pregnancies relative to unaffected pregnancies (15).

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