human placental lactogen


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Related to human placental lactogen: estrogen, HCG, prolactin, human chorionic gonadotropin

lactogen

 [lak´to-jen]
any substance that enhances lactation.
human placental lactogen (HPL) (hPL) a hormone secreted by the placenta, which disappears from the blood immediately after delivery. It has lactogenic, luteotropic, and growth-promoting activity, and inhibits maternal insulin activity during pregnancy.

hu·man pla·cen·tal lac·to·gen (HPL),

lactogen isolated from human placentas and structurally similar to somatotropin; its biologic activity weakly mimics that of somatotropin and prolactin; secreted into maternal circulation; a deficiency of HPL during pregnancy leads to children who undergo abnormal intrauterine and postnatal growth.

human placental lactogen

Chorionic somatomammotropin, hPL, human placental lactogen, human chorionic somatomammotropin A hormone produced during implantation of a fertilized egg, and secreted by the placenta; hPL regulates and coordinates fetal growth and metabolism and maternal metabolism Maternal effects Relative insulin resistance, ↑ circulating free fatty acids; hPL may optimize metabolism of nutrients by the fetus in 1st half of pregnancy; in 2nd half, there is little correlation between hPL levels and fetal well-being; hPL stimulates milk production and breast enlargement, and is somatotopic and luteotropic; urine and plasma HPL levels reflect placental size and are higher in diabetic mothers Ref range Rises during gestation, plateauing at 37 wks at 10 mg/mL; ♂ <0.5 mg/mL; non-pregnant ♀ <0.5 mg/mL; wks of gestation 5-27 <4.6 mg/mL; 28-31 wks, 2.4-6.1 mg/mL; 32-35 wks, 3.7-7.7 mg/mL; 36 wks to term, 5-8.6 mg/mL; hPL is ↓ in postmaturity syndrome, retarded growth, toxemia of pregnancy, threatened abortion; it is ↑ DM, Rh isoimmunization, hydatiform mole, choriocarcinoma Critical value <4 μg/mL after 30 wks gestation

hu·man pla·cen·tal lac·to·gen

(hyū'măn plă-sen'tăl lak'tŏ-jen)
Any agent to stimulate human milk production that has been isolated from human placentas; its biologic activity mimics that of somatotropin and prolactin; secreted into maternal circulation; deficiency during pregnancy leads to abnormal intrauterine and postnatal growth.
Compare: bioregulator
Synonym(s): chorionic growth hormone-prolactin, human chorionic somatomammotropic hormone, placental growth hormone.
References in periodicals archive ?
Choriocarcinomatous cells are positive for hCG and human placental lactogen (Figure 2, C).
To find an early single marker for EP, several studies have measured placental markers (pregnancy-associated plasma protein A, serum-specific protein-1, human placental lactogen, and leukemia-inhibiting factor) and nonplacental proteins (glycodelin and vascular endothelial growth factor) and compared results for women with an EP with those for women with an intrauterine pregnancy (IUP) (8-10).
The authors of a previously reported microarray study reported that human placental lactogen (hPL) is highly expressed in both first- and third-trimester placental tissues, whereas human chorionic gonadotropin [beta]-subunit ([beta]hCG) is produced mainly in first-trimester placentas (4).
1A) and a placenta-specific mRNA, human placental lactogen (hPL) mRNA (10) (data not shown), were detected in the maternal plasma aliquots without formaldehyde treatment but in none of the paired aliquots treated with formaldehyde.

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