human monocytotropic ehrlichiosis

human monocytotropic ehrlichiosis (HME),

an acute infectious disease characterized by fever, chills, headache, muscle and joint pain, and variable respiratory, gastrointestinal, and systemic involvement; hematologic studies show depression of erythrocytes, leukocytes, and platelets. The finding of clumps of developing organisms, called morulae, in the cytoplasm of monocytes in a stained smear of peripheral blood establishes the diagnosis, but their detection is often difficult. Serologic testing shows antibody to Ehrlichia chaffeensis, an organism closely resembling the agent of canine ehrlichiosis, E. canis. This disease has been largely confined to the southeastern and south central United States. The Lone Star tick (Amblyomma americanum) and the American dog tick (Dermacentor variabilis) are the principal vectors. Incidence is highest from April to September, during the peak activity of these ticks. See: human ehrlichiosis, human granulocytotropic ehrlichiosis.
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Human monocytotropic ehrlichiosis is far more widespread and serious, and symptoms can range from almost none to toxic shock-like.
chaffeensis in human has been termed human monocytic ehrlichiosis or human monocytotropic ehrlichiosis (HME).
Human monocytotropic ehrlichiosis (HME): epidemiological, clinical and laboratory diagnosis of a newly emergent infection in the United States.
Western immunoblotting analysis of the antibody responses of patients with human monocytotropic ehrlichiosis to different strains of Ehrlichia chaffeensis and Ehrlichia canis.
Spatial analysis of the distribution of Ehrlichia chaffeensis, causative agent of human monocytotropic ehrlichiosis, across a multi-state region.
To determine the incidence, clinical and laboratory characteristics, and utility of molecular diagnosis of human monocytotropic ehrlichiosis (HME) in the primary care setting, we conducted a prospective study in an outpatient primary care clinic in Cape Girardeau, Missouri.
The clinical spectrum of human monocytotropic ehrlichiosis (HME) ranges from mild to a life-threatening multisystem disease (7-11) with a case-fatality rate of 2% to 3% and a duration of illness in the absence of antiehrlichial treatment averaging 3 weeks.
chaffeensis infections are common in free-ranging coyotes in Oklahoma and that these wild canids could play a role in the epidemiology of human monocytotropic ehrlichiosis.
Human monocytotropic ehrlichiosis, a tickborne zoonosis caused by the rickettsial pathogen Ehrlichia chaffeensis (Rickettsiales: Ehrlichieae), occurs primarily in the southern, southcentral, and mid-Atlantic regions of the United States (1,2).

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