human leukocyte antigens


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Related to human leukocyte antigens: HLA system, Hla antigens

hu·man leuko·cyte an·ti·gens (HLA),

[MIM*142560]
system designation for the major histocompatibility complex gene products of at least four linked loci (A, B, C, and D) and a number of subloci on the sixth human chromosome that have been shown to have a strong influence on human allotransplantation, transfusions in refractory patients, immune responsiveness to certain antigens, and certain disease associations; autosomal dominant inheritance. See: major histocompatibility complex.

human leukocyte antigens

See HLA.

hu·man leu·ko·cyte an·ti·gens

(HLA) (hyū'măn lū'kō-sīt an'ti-jen)
Any of several members of a system consisting of the gene products of at least four linked loci (A, B, C, and D) and a number of subloci on the sixth human chromosome that have been shown to have a strong influence on human allotransplantation, transfusions in refractory patients, and certain disease associations; more than 50 alleles are recognized, most of which are at loci HLA-A and HLA-B; autosomal dominant inheritance.
References in periodicals archive ?
Among the genetic predisposing factors, human leukocyte antigen (HLA) genes have been reported to be associated with NPC.
sup][4] Among all genetic factors, human leukocyte antigen ( HLA ) genes have been shown to have a strong and consistent association with NPC risk.
Human leukocyte antigen class I alleles and haplotypes associated with primary hepatocellular carcinoma in persistent HBV-infected patients.
Table 1: Observed numbers and percentage frequencies of human leukocyte antigen (HLA)-class I (A and B) alleles in the pulmonary tuberculosis patients and controls HLA Pulmonary Controls P value Alleles Tuberculosis (No=40) Patients (No =105) No % No % A1 20 19.
The problem is that only about 60% will have an ideal donor, in which all six markers, known as human leukocyte antigens (HLA), match.
Alzheimer researchers are finding increasing evidence of immune components in the brain, including T cells, natural killer cells and human leukocyte antigens.

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