human leukocyte antigen

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human leukocyte antigen (HLA)

any one of four significant histocompatibility antigens governed by genes of the HLA complex, specific loci on chromosome 6, designated HLA-A, HLA-B, HLA-C, and HLA-D. Each locus has several genetically determined alleles; each of these is associated with certain diseases or conditions; for example, HLA-B27 is usually present in people who have ankylosing spondylitis. The HLA system is used to assess tissue compatibility. White blood cells are used for testing. Perfect tissue compatibility exists only between identical twins. See also histocompatibility gene.

human leukocyte antigen (HLA)


human leukocyte antigen

; HLA antigenic molecules that form the major histocompatibility complex (MHC), determining graft/host tissue compatibility (by identification of 'self 'or 'non-self' tissue moieties) and allowing tissue typing (see HLA B27)

hu·man leu·ko·cyte an·ti·gen

(HLA) (hyū'măn lū'kō-sīt an'ti-jen)
Any of several members of a system consisting of the gene products of at least four linked loci (A, B, C, and D) and a number of subloci on the sixth human chromosome that have been shown to have a strong influence on human allotransplantation, transfusions in refractory patients, and some disease associations.

human leukocyte antigen (HLA),

n a collection of human genes on chromosome 6 that encode proteins that function in cells to transport antigens from within the cell to the cell surface. These proteins are sometimes referred to as the MHC, or major histocompatibility complex.


see homo-.

human carriers
humans who act as active carriers of diseases of animals and infect animals.
human immunodeficiency virus
includes HIV1 (more common) and HIV2 which are lentiviruses that cause acquired immunodeficiency disease (AIDS) in humans.
human leukocyte antigen
see major histocompatibility complex.
References in periodicals archive ?
Human leukocyte antigen typing for all patients was performed in the same laboratory.
today announced the commercial availability of the HLASeq[TM] Research Screening Panel, a comprehensive genetic screening solution for human leukocyte antigen (HLA) and major histocompatibility complex (MHC) research using next-generation sequencing technology.
Healthcare providers at these institutions in Taiwan are utilizing Pharmigene's genetic test used to detect the presence of a key human leukocyte antigen (HLA) allele, HLA-B*1502, in individual patients being considered for treatment with the drug carbamazepine.
Linkage Biosciences, a molecular diagnostics company and leader in Human Leukocyte Antigen (HLA) typing and associated products, announced that it recently raised $2 million in growth capital.
Johns Hopkins researchers from the Center for Inherited Disease Research confirmed that a gene in the human leukocyte antigen (HLA) region was strongly linked with Parkinson's disease; this region contains a large number of genes related to immune system function.
The elite controllers tend to have more of a specific type of HIV-directed CD4 and CD8 T cells, and to have a particular haplotype of the human leukocyte antigen (HLA) molecule expressed by antigen presenting cells.
His work builds on research showing Type I diabetics have a genetic flaw resulting in the substitution of an amino acid occupying a specific position in a type of human leukocyte antigen protein (SN: 10/17/87, p.
The Food and Drug Administration has determined that individuals testing positive for a particular human leukocyte antigen (HLA) allele, HLA-B*1502, in their DNA should not be treated with carbamazepine, a drug used for epilepsy, trigeminal neuralgia, and bipolar disorder.
Contract award: reagents and human leukocyte antigen typing in high resolution.
AE37 represents the only HER2-based peptide vaccine currently being studied in a randomized trial and its use is not restricted to patients with a particular type of human leukocyte antigen (HLA) peptide.
In a two-way kidney swap, patient A is incompatible with donor A--because of blood type and/or human leukocyte antigen (HLA) profile--and patient B is incompatible with donor B.
Build an inventory of the highest quality cord blood units for use as unrelated donor grafts for patients who lack human leukocyte antigen (HLA)-matching sibling donors, and

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