human leukocyte antigen

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human leukocyte antigen (HLA)

any one of four significant histocompatibility antigens governed by genes of the HLA complex, specific loci on chromosome 6, designated HLA-A, HLA-B, HLA-C, and HLA-D. Each locus has several genetically determined alleles; each of these is associated with certain diseases or conditions; for example, HLA-B27 is usually present in people who have ankylosing spondylitis. The HLA system is used to assess tissue compatibility. White blood cells are used for testing. Perfect tissue compatibility exists only between identical twins. See also histocompatibility gene.

human leukocyte antigen (HLA)


human leukocyte antigen

; HLA antigenic molecules that form the major histocompatibility complex (MHC), determining graft/host tissue compatibility (by identification of 'self 'or 'non-self' tissue moieties) and allowing tissue typing (see HLA B27)

hu·man leu·ko·cyte an·ti·gen

(HLA) (hyū'măn lū'kō-sīt an'ti-jen)
Any of several members of a system consisting of the gene products of at least four linked loci (A, B, C, and D) and a number of subloci on the sixth human chromosome that have been shown to have a strong influence on human allotransplantation, transfusions in refractory patients, and some disease associations.

human leukocyte antigen (HLA),

n a collection of human genes on chromosome 6 that encode proteins that function in cells to transport antigens from within the cell to the cell surface. These proteins are sometimes referred to as the MHC, or major histocompatibility complex.


see homo-.

human carriers
humans who act as active carriers of diseases of animals and infect animals.
human immunodeficiency virus
includes HIV1 (more common) and HIV2 which are lentiviruses that cause acquired immunodeficiency disease (AIDS) in humans.
human leukocyte antigen
see major histocompatibility complex.
References in periodicals archive ?
Human leukocyte antigen typing for all patients was performed in the same laboratory.
Olerup SSP, based in Saltsjobaden, Sweden, develops reagents and kits for Human Leukocyte Antigen typing used in matching bone marrow donors with recipients.
DAISY was a prospective observational study involving 1,770 unaffected children who were either first-degree relatives of patients with type 1 diabetes or who carried a high-risk human leukocyte antigen (HLA) genotype.
In a two-way kidney swap, patient A is incompatible with donor A--because of blood type and/or human leukocyte antigen (HLA) profile--and patient B is incompatible with donor B.
This epitope discovery technology can also be used to optimize patient selection for clinical trials by identifying peptides that are more likely to be immunogenic in specific patient populations based on the population's human leukocyte antigen, or HLA, types.
Nevertheless, the sensitivity of this assay to detect CD8(+) T cells could be improved by using human leukocyte antigen (HLA) class I specific peptides as previously described (4).
454 Life Sciences, a Roche Company, announced today the launch and immediate availability of the new GS GType HLA Primer Sets for high- and medium-resolution genotyping of class I and class II loci of the Human Leukocyte Antigen (HLA) genes.
Proprietary molecule, D-MDOPA, is being developed as lead candidate, IMT-002, to inhibit the autoimmune cascade in recent onset T1D patients with the human leukocyte antigen -DQ8 gene.
The study of genes in the human leukocyte antigen region of the human genome, HLA typing, is key for research in tissue transplantation matching, autoimmune disease-association studies, drug hypersensitivity research, and other applications.
The main gene associated with MS is the human leukocyte antigen (HLA) class II gene, but most of the risk comes from interaction of both parental genes.
Transplant pioneer Jean Dausset, MD, the French Nobel laureate who discovered the human leukocyte antigen (HLA) system that made human tissue typing for transplantation possible, died of natural causes June 6, 2009 in Mallorca, Spain.

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