human leukocyte antigen


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human leukocyte antigen (HLA)

any one of four significant histocompatibility antigens governed by genes of the HLA complex, specific loci on chromosome 6, designated HLA-A, HLA-B, HLA-C, and HLA-D. Each locus has several genetically determined alleles; each of these is associated with certain diseases or conditions; for example, HLA-B27 is usually present in people who have ankylosing spondylitis. The HLA system is used to assess tissue compatibility. White blood cells are used for testing. Perfect tissue compatibility exists only between identical twins. See also histocompatibility gene.

human leukocyte antigen (HLA)

The human MAJOR HISTOCOMPATIBILITY COMPLEX.

human leukocyte antigen

; HLA antigenic molecules that form the major histocompatibility complex (MHC), determining graft/host tissue compatibility (by identification of 'self 'or 'non-self' tissue moieties) and allowing tissue typing (see HLA B27)

hu·man leu·ko·cyte an·ti·gen

(HLA) (hyū'măn lū'kō-sīt an'ti-jen)
Any of several members of a system consisting of the gene products of at least four linked loci (A, B, C, and D) and a number of subloci on the sixth human chromosome that have been shown to have a strong influence on human allotransplantation, transfusions in refractory patients, and some disease associations.

human leukocyte antigen (HLA),

n a collection of human genes on chromosome 6 that encode proteins that function in cells to transport antigens from within the cell to the cell surface. These proteins are sometimes referred to as the MHC, or major histocompatibility complex.

human

see homo-.
human carriers
humans who act as active carriers of diseases of animals and infect animals.
human immunodeficiency virus
includes HIV1 (more common) and HIV2 which are lentiviruses that cause acquired immunodeficiency disease (AIDS) in humans.
human leukocyte antigen
see major histocompatibility complex.
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References in periodicals archive ?
Human leukocyte antigens and genetic susceptibility to lymphoma.
Associations of Human Leukocyte Antigen-DRB1 Alleles with Nasopharyngeal Carcinoma and Its Clinical Significance in Xinjiang Uyghur Autonomous Region of China
Human leukocyte antigen typing for all patients was performed in the same laboratory.
Human leukocyte antigen alleles and haplotypes associated with chronicity of hepatitis B virus infection in Koreans
Olerup SSP, based in Saltsjobaden, Sweden, develops reagents and kits for Human Leukocyte Antigen typing used in matching bone marrow donors with recipients.
LinkMed AB completes acquisition of Olerup SSP AB
DAISY was a prospective observational study involving 1,770 unaffected children who were either first-degree relatives of patients with type 1 diabetes or who carried a high-risk human leukocyte antigen (HLA) genotype.
Omega-3 fats may cut risk of diabetes in at-risk kids
In a two-way kidney swap, patient A is incompatible with donor A--because of blood type and/or human leukocyte antigen (HLA) profile--and patient B is incompatible with donor B.
Kidney swaps could expand living donor transplantation options
This epitope discovery technology can also be used to optimize patient selection for clinical trials by identifying peptides that are more likely to be immunogenic in specific patient populations based on the population's human leukocyte antigen, or HLA, types.
Immunology in the 21st century: innovative tools in T-cell immunology
Nevertheless, the sensitivity of this assay to detect CD8(+) T cells could be improved by using human leukocyte antigen (HLA) class I specific peptides as previously described (4).
Flow cytometry and T-cell response monitoring after smallpox vaccination
454 Life Sciences, a Roche Company, announced today the launch and immediate availability of the new GS GType HLA Primer Sets for high- and medium-resolution genotyping of class I and class II loci of the Human Leukocyte Antigen (HLA) genes.
Roche Introduces Next-Generation HLA Typing Solution for 454 Sequencing Systems
Proprietary molecule, D-MDOPA, is being developed as lead candidate, IMT-002, to inhibit the autoimmune cascade in recent onset T1D patients with the human leukocyte antigen -DQ8 gene.
ImmunoMolecular Therapeutics Issued Two Patents for Small Molecule Therapies in Type 1 Diabetes and Celiac Disease
The study of genes in the human leukocyte antigen region of the human genome, HLA typing, is key for research in tissue transplantation matching, autoimmune disease-association studies, drug hypersensitivity research, and other applications.
United States : HistoGenetics secures deal to perform HLA typing using PacBio sequencing
The main gene associated with MS is the human leukocyte antigen (HLA) class II gene, but most of the risk comes from interaction of both parental genes.
Women at higher genetic risk for multiple sclerosis: Study
Transplant pioneer Jean Dausset, MD, the French Nobel laureate who discovered the human leukocyte antigen (HLA) system that made human tissue typing for transplantation possible, died of natural causes June 6, 2009 in Mallorca, Spain.
Jean Dausset, MD

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