human immune globulin

human immune globulin

A therapeutic prepared from a donor pool screened and negative for HIV-1 Indications for use Primary immunodeficiencies–eg, X-linked agammaglobulinemia, SCID and combined variable immune deficiency, and in acute or chronic ITP. See Immunoglobulin.
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Indications and updated dosage recommendations for GamaSTAN S/D human immune globulin for preexposure and postexposure prophylaxis against hepatitis A infection Indication Updated dosage recommendation Preexposure prophylaxis Up to 1 month of travel 0.1 mL/kg Up to 2 months of travel 0.2 mL/kg 2 months of travel or longer 0.2 mL/kg (repeat every 2 months) Postexposure prophylaxis 0.1 mL/kg
The product is a combination of human immune globulin and recombinant human hyaluronidase.
For example, in a comparison of the activity of human MAbs with that of human immune globulin, 0.7 mg of a mixture of two MAbs had the same neutralizing activity as 100 mg-170 mg of tetanus immune globulin (90).
"Dear Healthcare Provider" letters, issued by both organizations, advised caution when prescribing and infusing intravenous human immune globulin (IVIg) to patients with cardiovascular disease or previous thrombotic events.
The investigational VariZIG, similar to licensed VZIG, is a purified human immune globulin preparation made from plasma containing high levels of anti-varicella antibodies (immunoglobulin class G [IgG]).
Contraindications for VariZIG administration include a history of anaphylactic or severe systemic reactions to human immune globulins and IgA-deficient patients with antibodies against IgA and a history of hypersensitivity (2).

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