human herpesvirus 8


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Related to human herpesvirus 8: Human herpesvirus 6, Kaposi Sarcoma

human herpesvirus 8 (HHV8),

a linear double-stranded DNA virus that induces Kaposi sarcoma (KS) in immunodeficient people. DNA sequences unique to this virus are regularly found in KS specimens from HIV-negative people as well. The virus is also associated with several uncommon lymphoproliferative syndromes in AIDS patients, including multicentric Castleman disease and primary effusion lymphoma (body cavity-based lymphoma). Limited studies suggest that it sometimes causes a self-limited febrile exanthem in immunocompetent children.

Among people with AIDS, KS occurs in 15-25% of male homosexuals but only in 1-3% of those who acquire AIDS by nonsexual routes. These facts support the hypothesis that the virus is sexually transmitted. KS is characterized histologically by abnormal vascularization and the presence of proliferating endothelial cells, fibroblasts, infiltrating leukocytes, and spindle-shaped tumor cells. Replication of HHV8 occurs only in a small subset of spindle cells, but most such cells are latently infected. Spindle cell proliferation is apparently triggered by growth factors released from HIV-infected cells. Spindle cells, in turn, produce factors that promote angiogenesis. HHV8 DNA can also be found in circulating CD19 B lymphocytes in 40-50% of AIDS patients with KS. Serologic assays are available for anti-HHV8 antibodies, most of them using viral antigen from cell lines derived from body cavity-based lymphomas. Viral replication is insensitive to acyclovir, but is inhibited by ganciclovir, foscarnet, cidofovir, and interferon alfa.

hu·man her·pes·vi·rus 8

(hyū'măn hĕr'pēz-vī'rŭs)
A linear double-stranded DNA virus that induces Kaposi sarcoma (KS) in immunodeficient people. DNA sequences unique to this virus are regularly found in KS specimens from HIV-negative people as well. The virus is also associated with several uncommon lymphoproliferative syndromes in AIDS patients, including multicentric Castleman disease and primary effusion lymphoma (body cavity-based lymphoma).

human herpesvirus 8

A herpes virus that causes KAPOSI'S SARCOMA in people with immune deficiency, especially AIDS. The virus is also associated with several otherwise rare forms of lymphoma that occur in AIDS patients.
References in periodicals archive ?
Thurau et al., "A systems biology approach to identify the combination effects of human herpesvirus 8 genes on NF-[kappa]B activation," Journal of Virology, vol.
Hermouet et al., "Plasma-cell leukemia and human herpesvirus 8 infection," Leukemia, vol.
Correlates of human herpesvirus 8 seropositivity among heterosexual men in Kenya.
Plasmablastic microlymphoma occurring in human herpesvirus 8 (HHV-8)-positive multicentric Castleman's disease and featuring a follicular growth pattern.
Human herpesvirus 8 epidemiology: what we do and do not know.
Herpesviruses that can establish latent and long-term infection in host humans include cytomegalovirus (CMV) or human herpesvirus 5 (HHV-5), Kaposi's sarcoma-associated herpesvirus (KSHV) or human herpesvirus 8 (HHV-8), and Epstein-Barr virus (EBV).
Human herpesvirus 8 is likely a relatively ubiquitous virus.
Human herpesvirus 8 transmission from mother to child and between siblings in an endemic population.
Human herpesvirus 8 (HHV-8) is considered as the etiological agent of all forms of Kaposi's sarcoma (KS), a tumor that frequently occurs during HIV infection (epidemic KS [AIDS-KS]) transplant recipients (iatrogenic KS), elderly men of Mediterranean and Middle Eastern origin (classic KS), and inhabitants of eastern and central Africa (endemic KS) [1,2].
There is an association between MCD and AIDS-associated Kaposi's sarcoma (KS) caused by human herpesvirus 8 (HHV8) or Kaposi's sarcoma herpesvirus (KSHV).
Human herpesvirus 8 (HHV8), shed mainly in saliva, is important in KS development.
Some NHL in HIV-infected patients has been attributed to deficient immune surveillance of oncogenic herpesviruses, such as Epstein-Barr virus (EBV) and human herpesvirus 8 (HHV-8), or perhaps to chronic antigenic stimulation and defective immune regulation.