human herpesvirus 8


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Related to human herpesvirus 8: Human herpesvirus 6, Kaposi Sarcoma

human herpesvirus 8 (HHV8),

a linear double-stranded DNA virus that induces Kaposi sarcoma (KS) in immunodeficient people. DNA sequences unique to this virus are regularly found in KS specimens from HIV-negative people as well. The virus is also associated with several uncommon lymphoproliferative syndromes in AIDS patients, including multicentric Castleman disease and primary effusion lymphoma (body cavity-based lymphoma). Limited studies suggest that it sometimes causes a self-limited febrile exanthem in immunocompetent children.

Among people with AIDS, KS occurs in 15-25% of male homosexuals but only in 1-3% of those who acquire AIDS by nonsexual routes. These facts support the hypothesis that the virus is sexually transmitted. KS is characterized histologically by abnormal vascularization and the presence of proliferating endothelial cells, fibroblasts, infiltrating leukocytes, and spindle-shaped tumor cells. Replication of HHV8 occurs only in a small subset of spindle cells, but most such cells are latently infected. Spindle cell proliferation is apparently triggered by growth factors released from HIV-infected cells. Spindle cells, in turn, produce factors that promote angiogenesis. HHV8 DNA can also be found in circulating CD19 B lymphocytes in 40-50% of AIDS patients with KS. Serologic assays are available for anti-HHV8 antibodies, most of them using viral antigen from cell lines derived from body cavity-based lymphomas. Viral replication is insensitive to acyclovir, but is inhibited by ganciclovir, foscarnet, cidofovir, and interferon alfa.

human herpesvirus 8

a virus in the family Herpesviridae that has been implicated as the causative agent of Kaposi's sarcoma, a rare form of cancer occasionally seen in AIDS patients, and primary effusion lymphoma. The predominant route of transmission is sexual activity. The virus may also be transmitted through blood contact in IV drug use. Treatment is currently experimental. Also called Kaposi's sarcoma-associated herpesvirus. See also Kaposi's sarcoma, primary effusion lymphoma.

hu·man her·pes·vi·rus 8

(hyū'măn hĕr'pēz-vī'rŭs)
A linear double-stranded DNA virus that induces Kaposi sarcoma (KS) in immunodeficient people. DNA sequences unique to this virus are regularly found in KS specimens from HIV-negative people as well. The virus is also associated with several uncommon lymphoproliferative syndromes in AIDS patients, including multicentric Castleman disease and primary effusion lymphoma (body cavity-based lymphoma).

human herpesvirus 8

A herpes virus that causes KAPOSI'S SARCOMA in people with immune deficiency, especially AIDS. The virus is also associated with several otherwise rare forms of lymphoma that occur in AIDS patients.
References in periodicals archive ?
Incidence of Human Herpesvirus 8 (HHV-8) infection among HIV-uninfected individuals at high risk for sexually transmitted infections.
Primary effusion lymphoma: cytopathologic diagnosis using in situ molecular genetic analysis for human herpesvirus 8.
Correlates of human herpesvirus 8 seropositivity among heterosexual men in Kenya.
Plasmablastic microlymphoma occurring in human herpesvirus 8 (HHV-8)-positive multicentric Castleman's disease and featuring a follicular growth pattern.
Identify and understand important and diverse types of therapeutics under development for Human Herpesvirus 8 (HHV-8) Infections.
Human herpesvirus 8 epidemiology: what we do and do not know.
Human herpesvirus 8 is the causative organism of Kaposi sarcoma, which, in the United States, occurs most frequently in association with immunosuppression, primarily human immunodeficiency virus infection.
Water, socioeconomic factors, and human herpesvirus 8 infection in Ugandan children and their mothers.
Some NHL in HIV-infected patients has been attributed to deficient immune surveillance of oncogenic herpesviruses, such as Epstein-Barr virus (EBV) and human herpesvirus 8 (HHV-8), or perhaps to chronic antigenic stimulation and defective immune regulation.
He had no Kaposi's lesions but was seropositive for human herpesvirus 8.
To the Editor: Human herpesvirus 8 (HHV-8) is the etiologic agent of Kaposi sarcoma.
Human herpesvirus 8 was not expressed in any of the control cases.