Chromosomally integrated human herpesvirus 6
: questions and answers.
Carrigan, "Human herpesvirus 6
and multiple sclerosis: systemic active infections in patients with early disease," Clinical Infectious Diseases, vol.
Topping the list was parvovirus B19, present in 51% of biopsies, followed by human herpesvirus 6
in 22%, enterovirus in 9%, Epstein-Barr virus in 2%, adenovirus in 1.6%, and cytomegalovirus in fewer than 1%.
Human herpesvirus 6
(HHV-6) acquisition was associated with female sex (adjusted hazard ratio of 1.7) and having older siblings (adjusted hazard ratio of 2.1).
Actually, its most accurate medical name is now human herpesvirus 6
(HHV-6), the virus that was found to cause this malady about eight years ago.
While the above discussion has been hypothetical and general in nature, no discussion of the utility of pairing MDx with serological methods would be complete without consideration of one widely recognized specific example--that of HHV-6 (human herpesvirus 6
To analyze EBNA-1 reaction specificity, DNA from the Epstein Barr virus (PEBNA-1 and RAJI cell line), from the human members of the Herpesviridae family (herpes simplex virus, cytomegalovirus, varicella-zoster virus, human herpesvirus 6
and human herpesvirus 8), from different origin human cells (fibroblast, human embryonic kidney (HEK-293) cell lines) and commercial source human DNA (Human Genomic DNA, Roche) were analysed.
The presence of human herpesvirus 6
antigen in SHML tissues has been reported in the literature.
(4) Proposed inciting agents include EBV, (5) human herpesvirus 6
and human herpesvirus 8, (6) human immunodeficiency virus (7) and parvovirus B19, (8) and paramyxoviruses, parainfluenza virus, Yersinia enterocolitica, and toxoplasma.
Congenital infections occur with human herpesvirus 6
(HHV-6) but not with the closely related human herpesvirus 7 (HHV-7), investigators reported (J.
One study caused a stir by suggesting that human herpesvirus 6
might be a frequent cause of febrile convulsions in young children, but results of a subsequent study contradicted that: It found that the rate of human herpes virus 6 among children was no different between those who had febrile seizures and those who didn't