human chorionic gonadotropin


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gonadotropin

 [go´nah-do-tro″pin]
any hormone having a stimulating effect on the gonads. Two such hormones are secreted by the anterior pituitary gland: follicle-stimulating hormone and luteinizing hormone, both of which are active, but with differing effects, in the two sexes. Called also gonadotropic hormone.
chorionic gonadotropin (human chorionic gonadotropin (HCG) (hCG))
1. a glycopeptide hormone that is produced by cells of the fetal placenta and maintains the function of the corpus luteum during the first few weeks of pregnancy. It is thought to promote steroidogenesis in the fetoplacental unit and to stimulate fetal testicular secretion of testosterone. It can be detected by immunoassay in the maternal urine within days after fertilization; this provides the basis for the most commonly used pregnancy test.
2. the same principle obtained from the urine of pregnant women, used in treatment of certain cases of cryptorchidism and male hypogonadism, to induce ovulation and pregnancy in certain infertile, anovulatory women, and to increase the numbers of oocytes for patients attempting conception using assisted reproductive technologies such as gamete intrafallopian transfer or in vitro fertilization; administered intramuscularly. See also choriogonadotropin alfa.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

cho·ri·on·ic go·nad·o·tro·pin (CG),

a glycoprotein with a carbohydrate fraction composed of d-galactose and hexosamine, extracted from the urine of pregnant women and produced by the placental trophoblastic cells; its most important role appears to be stimulation, during the first trimester, of ovarian secretion of the estrogen and progesterone required for the integrity of conceptus; it appears to play no significant role in the last two trimesters of pregnancy, as the estrogen and progesterone are then formed by the placenta. CG has luteinizing hormone activity and exerts its actions through luteinizing hormone receptors.
Farlex Partner Medical Dictionary © Farlex 2012

human chorionic gonadotropin

n. Abbr. HCG
A hormone produced by the placenta that maintains the corpus luteum during pregnancy.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

human chorionic gonadotropin

See hCG.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

cho·ri·on·ic go·nad·o·tro·pin

(kōr'ē-on'ik gō-nad'ō-trō'pin)
A glycoprotein with a carbohydrate fraction composed of d-galactose and hexosamine, produced by the placental trophoblastic cells; its most important role appears to be stimulation (during the first trimester) of ovarian secretion of the estrogen and progesterone required for the integrity of the conceptus; it appears to play no significant role in the last two trimesters of pregnancy, because the estrogen and progesterone are then formed by the placenta. Testing for the beta fraction of human chorionic gonadotropin is the basis for most serum and urine pregnancy tests.
Synonym(s): anterior pituitarylike hormone, chorionic gonadotropic hormone, chorionic gonadotrophic hormone.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

human chorionic gonadotropin (HCG)

a gonadotrophic hormone secreted by the chorion of the PLACENTA (1) that has a similar effect to luteinizing hormone (see LH).
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005

Human chorionic gonadotropin (hCG)

A hormone excreted during the development of an embryo or fetus.
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.

Patient discussion about human chorionic gonadotropin

Q. Does a slow rise in HCG hormone during pregnancy a condition to worry? My wife is in second trimester of pregnancy and had a HCG test, which shows fewer levels as compared to previous results. Does a slow rise in HCG hormone during pregnancy a condition to worry?

A. When you have a hCG test in the start of pregnancy, the level of hCG in your blood must increase to double in 2-3 days. While the hCG doubling time will slow down from the mid of the first trimester and hCG level also begin to slowly reduce from 4th month onwards. Thus at this stage there is nothing to worry about, it is normal.

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References in periodicals archive ?
Falsely Decreased Human Chorionic Gonadotropin (hCG) Results Due to Increased Concentrations of the Free {beta} Subunit and the {beta} Core Fragment in Quantitative hCG Assays.
Determination of gestational age by serum concentrations of human chorionic gonadotropin. Obstet Gynecol 1983; 61:37-40.
Their average MoM was 1.19 for alpha-fetoprotein, 1.31 for human chorionic gonadotropin, and 1.36 for dimeric inhibin A.
Evidence for the presence of human chorionic gonadotropin (hCG) and free beta-subunit of hCG in the human pituitary.
The most extensive work so far involves vaccines made of a subunit of the hormone human chorionic gonadotropin (beta-hCG).
The development of these tests, which are based on the detection of human chorionic gonadotropin (hCG) [2] in the urine, came 50 years after the discovery of hCG by Aschheim and Zondek (2) and after several centuries of descriptions of many other pregnancy tests.
(1) As the authors mentioned, this phenomenon is still underdiagnosed--less so today than in 1961, when we did without the benefit of both ultrasonography and the ability to rapidly and accurately measure human chorionic gonadotropin (hCG) levels.
A The current version of CAP checklist item 06.3430 and its counterpart in other checklists, essentially unchanged since 1994, read as follows: "Are known positive and negative controls run on each day of analysis with each run of specimens for all qualitative or semiquantitative serologic tests (e.g., rheumatoid factor, rapid plasma reagin, ASO, human chorionic gonadotropin [hCG], heterophile antibody, etc.)?"
Persistent Low Concentration of Human Chorionic Gonadotropin in a Nonpregnant Woman (11 756) Authors: Christopher R.
Absence of a surge indicates the likely absence of ovulation, which can be treated by giving 10,000 IU of human chorionic gonadotropin (hCG) subcutaneously or intramuscularly when the largest follicle is 18 to 25 mm in size.
Previously, we reported false-negative results generated by the OSOM human chorionic gonadotropin (hCG) [1] Combo test (Genzyme Diagnostics) (1) and certain lots of the hCG Cardinal Health Combo SP brand rapid test device (SP hCG rapid test; Cardinal Health) (2) owing to increased concentrations of hCG [beta] core fragment (hCG [beta]cf).

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