alpha1-antitrypsin

(redirected from human alpha1-protease inhibitor)

α1-an·ti·tryp·sin

A glycoprotein that is the major protease inhibitor of human serum, is synthesized in the liver, and is genetically polymorphic due to the presence of 25 alleles; people appropriately homozygous are deficient in α1-trypsin and are predisposed to pulmonary emphysema and juvenile hepatic cirrhosis because of alterations in the amino acid and sialic acid components of the glycoprotein. The concentration of α1-antitrypsin increases in response to injury or infection. α1-Antitrypsin also inhibits thrombin and elastase.

α1-an·ti·tryp·sin

(an'tē-trip'sin)
A glycoprotein that is the major protease inhibitor of human serum, is synthesized in the liver, and is genetically polymorphic due to the presence of 25 alleles; people appropriately homozygous are deficient in α1-trypsin and are predisposed to pulmonary emphysema and juvenile hepatic cirrhosis because of alterations in the amino acid and sialic acid components of the glycoprotein.
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