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factor IX (human)

AlphaNine SD, Immune VH (CA), Mononine

factor IX (recombinant)

BeneFix

factor IX complex

Bebulin VH, Defix (UK), Hipfix (UK), Octaplex (CA), Profilnine SD, Proplex T (heat-treated), Replenine (UK)

Pharmacologic class: Blood modifier

Therapeutic class: Antihemophilic

Pregnancy risk category C

Action

Converts fibrinogen to fibrin, increasing levels of clotting factors

Availability

Powder for injection: Various strengths; units specified on label

Indications and dosages

Factor IX deficiency (hemophilia B or Christmas disease); anticoagulant overdose

Adults and children: Dosage individualized; drug administered I.V. Use following equations to calculate approximate units needed:

Human product-1 unit/kg times body weight (in kg) times desired increase in factor IX level, expressed as percentage of normal

Recombinant product-1.2 units/kg times body weight (in kg) times desired increase in factor IX level, expressed as percentage of normal

Proplex T-0.5 unit/kg times body weight (in kg) times desired increase in factor IX level, expressed as percentage of normal

Off-label uses

• Hepatic dysfunction

• Esophagitis

• Unspecified GI hemorrhage (human product)

Contraindications

• Hypersensitivity to mouse or hamster protein (with BeneFix)

• Fibrinolysis

Precautions

Use cautiously in:

• recent surgery

• pregnant patients

• children younger than age 6 (safety and efficacy not established).

Administration

Give by slow I.V. infusion. Average infusion rate is 100 units (2 to 3 ml)/minute; don't exceed 10 ml/minute.

• If prescribed, administer hepatitis B vaccine before giving factor IX.

• Know that dosage is highly individualized according to degree of factor IX deficiency, patient's weight, and bleeding severity.

• Don't use glass syringe. Don't shake reconstituted solution or mix with other I.V. solutions.

Adverse reactions

CNS: light-headedness, paresthesia, headache

CV: blood pressure changes, thromboembolic reactions, myocardial infarction (MI)

EENT: allergic rhinitis

GI: nausea, vomiting

Hematologic: disseminated intravascular coagulation (DIC)

Respiratory: pulmonary embolism

Skin: rash, flushing, diaphoresis, pruritus, urticaria

Other: altered taste, fever, chills, burning sensation in jaw and skull, pain at I.V. injection site, hypersensitivity reactions including anaphylaxis

Interactions

Drug-drug. Aminocaproic acid: increased risk of thrombosis

Patient monitoring

• Be aware that factor IX complex may transmit hepatitis.

• Closely monitor vital signs during infusion.

Observe for hemolytic reaction. If it occurs, stop infusion, flush line with saline solution, and notify prescriber immediately.

• Monitor I.V. injection site closely.

Monitor coagulation studies closely. Know that drug may cause thromboembolic disorders, including MI and DIC.

Patient teaching

• Inform patient that drug may transmit diseases.

Tell patient to immediately report signs and symptoms of hypersensitivity reaction, including rash, hives, tightness in chest, wheezing, shortness of breath, and swelling of throat or lips.

Advise patient to immediately report unusual bleeding or bruising.

• Caution patient to avoid activities that can cause injury.

• Tell patient to wear medical identification stating that he has a blood-clotting disorder.

• Instruct patient to notify surgeon or dentist of his blood-clotting disorder before surgery or invasive dental procedures.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs mentioned above.

human

(hyo͞o′mən)
n.
A member of the primate genus Homo, especially a member of the species Homo sapiens, distinguished from other apes by a large brain and the capacity for speech.
adj.
Of, relating to, or characteristic of humans: the course of human events; the human race.

hu′man·hood′ n.
hu′man·ness n.

human

[h(y)o̅o̅′mən]
Etymology: L, humanus
a member of the genus Homo and particularly of the species H. sapiens.

human

see homo-.

human carriers
humans who act as active carriers of diseases of animals and infect animals.
human immunodeficiency virus
includes HIV1 (more common) and HIV2 which are lentiviruses that cause acquired immunodeficiency disease (AIDS) in humans.
human leukocyte antigen
see major histocompatibility complex.

Patient discussion about human

Q. I am a man with breast cancer. Hello friends, you might have heard about breast cancer in women but here I am a man with breast cancer. Is Herceptin licensed to treat me?

A. Hi, what were your symptoms and when did you discover you had breast cancer?

Q. what are the basics products we as a humans, need to have in our diet?

A. A regular healthy diet should be comprised of a 40-50% carbohydrate (bread, rice, etc.), 30-40% protein (dairy, meat, chicken, fish) and 20% fat. Other important ingredients are fruit and vegetables, that contain large amounts of fibers and vitamins.

Q. Is there a difference between a man's diet and a woman's diet? let say for the point of it the weight the same and they are in the same age .

A. no one should have the same exact diet, you need to find what works for you and helps you achieve your goals.

the base of the diet could be the same, for example burn calories then you consume. But other wise, find what works for you.

More discussions about human
References in classic literature ?
But in Jerry's vocabulary, "Mister Haggin" possessed all the definiteness of sound and meaning that the word "master" possesses in the vocabularies of humans in relation to their dogs.
If it were thus,--as there comes in all human society a moment when the sacred symbol is worn out and becomes obliterated under freedom of thought, when man escapes from the priest, when the excrescence of philosophies and systems devour the face of religion,--architecture could not reproduce this new state of human thought; its leaves, so crowded on the face, would be empty on the back; its work would be mutilated; its book would he incomplete.
The leader of the human beings stepped forward with upraised hands.
They claimed exemption from the mandates of human authority, as militating with their subjection to a superior power.
He saw, too, that except for their wings the pair bore a strong resemblance to human beings, though fashioned in a most grotesque mold.
A hundred diseases, all the fevers and con- tagions of human life, consumption, cancers, tumours and such morbidities, never enter the scheme of their life.
Peter heard the little people crying everywhere that there was a human in the Gardens after Lock-out Time, but he never thought for a moment that he was the human.
Secondly, that what is commonly called love, namely, the desire of satisfying a voracious appetite with a certain quantity of delicate white human flesh, is by no means that passion for which I here contend.
It was with these feelings that I began the creation of a human being.
It may gratify the pride of aristocracy to reflect that disease, more than any other circumstance of human life, pays due observance to the distinctions which rank and wealth, and poverty and lowliness, have established among mankind.
There they see the divine forms of justice, temperance, and the like, in their unchangeable beauty, but not without an effort more than human.
It is clear that the question turns upon another, namely, which can we know best, the psychology of animals or that of human beings?