mule(redirected from horse mule)
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a person who transports illicit drugs by concealment in body cavities.
1. The sterile hybrid offspring of a male donkey and a female horse, characterized by long ears and a short mane.
2. A sterile hybrid, as between a canary and other birds or between certain plants.
HUWE1A gene on chromosome Xp11.22 that encodes E3 ubiquitin-protein ligase, which mediates ubiquitination and proteasomal degradation of target proteins. HUWE1 regulates apoptosis by catalysing the polyubiquitination and degradation of MCL1. It also plays a role in base-excision repair and in regulating neural differentiation and proliferation by polyubiquitination and degradation of MYCN. It may also regulate concentration of CDC6 after DNA damage by targeting it for degradation.
Defects in HUWE1 cause mental retardation, X-linked, syndromic Turner type (MXRST) and mental retardation, X-linked, type 17/31.