Epidemiological, immunological and practical consideration in developing and evaluating a human hookworm vaccine. Expert Rev Vacc 4: 35-50.
The human hookworm vaccines. Vaccine 315: B227-B232.
The topics include harnessing genomic technologies to explore the molecular biology of liver flukes, identifying and profiling nematicidal compounds in veterinary parasitology, drugs and targets to perturb the symbiosis of Wolbachia and filarial nematodes, the preclinical development of a human hookworm vaccine
, new approaches to antigen discovery and promising new candidates for schistosomiasis vaccines, and vaccines against cestode parasites.
1 February 2012 - The Infectious Disease Research Institute (IDRI) said on Tuesday that it is providing technical support to the Sabin Vaccine Institute's (Sabin) Phase I clinical trial of a human hookworm vaccine candidate, which kicked off in Brazil last week.
IDRI has provided the developers of the hookworm vaccine with its proprietary GLA-AF adjuvant to be used as a component of the vaccine, which is based on Sabin's Na-GST-1 antigen.
Hotez disclosed that he has a patent on a hookworm vaccine
, but no relationships with pharmaceutical companies.
Until new approaches become available, whether a hookworm vaccine
or improved sanitation infrastructures, deworming for school-age children remains the most practical way to control helminth infections in the developing world.